Literature DB >> 6389245

Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats.

U Helmchen, W E Schmidt, E G Siegel, W Creutzfeldt.   

Abstract

Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.

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Year:  1984        PMID： 6389245     DOI： 10.1007/bf00304861

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  7 in total

1.  Alpha cell cytotoxins; their influence on carbohydrate metabolism and the effect of the oral blood glucose reducing sulfonamides on the islet cells.

Authors:  W CREUTZFELDT
Journal:  Diabetes       Date:  1957 Mar-Apr       Impact factor: 9.461

2.  Clinical Aspects of Cyclosporine Therapy: A Summation.

Authors:  T E Starzl
Journal:  Transplant Proc       Date:  1983-12       Impact factor: 1.066

3.  Cyclosporin for pulmonary sarcoidosis.

Authors:  A S Rebuck; C R Stiller; A C Braude; A Laupacis; R D Cohen; K R Chapman
Journal:  Lancet       Date:  1984-05-26       Impact factor: 79.321

4.  Deterioration in glucose metabolism in pancreatic transplant recipients given cyclosporin.

Authors:  R Gunnarsson; G Klintmalm; G Lundgren; H Wilczek; J Ostman; C G Groth
Journal:  Lancet       Date:  1983-09-03       Impact factor: 79.321

5.  Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.

Authors:  C R Stiller; J Dupré; M Gent; M R Jenner; P A Keown; A Laupacis; R Martell; N W Rodger; B von Graffenried; B M Wolfe
Journal:  Science       Date:  1984-03-30       Impact factor: 47.728

Review 6.  Toxicological evaluation of cyclosporin A.

Authors:  B Ryffel; P Donatsch; M Madörin; B E Matter; G Rüttimann; H Schön; R Stoll; J Wilson
Journal:  Arch Toxicol       Date:  1983-06       Impact factor: 5.153

7.  Studies on the immunosuppressive properties of cyclosporin a in rats receiving renal allografts.

Authors:  W P Homan; J W Fabre; K A Williams; P R Millard; P J Morris
Journal:  Transplantation       Date:  1980-05       Impact factor: 4.939
  7 in total
  23 in total

1.  Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans.

Authors:  P B Carroll; A A Gonçalves; A C Boschero; A G Tzakis; T E Starzl; I Atwater
Journal:  Transplant Proc       Date:  1991-02       Impact factor: 1.066

2.  Effect of the immunosuppressant FK506 on glucose-induced insulin secretion from adult rat islets of Langerhans.

Authors:  P B Carroll; A C Boschero; M Y Li; A G Tzakis; T E Starzl; I Atwater
Journal:  Transplantation       Date:  1991-01       Impact factor: 4.939

3.  Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients.

Authors:  L Mieles; R D Gordon; D Mintz; R M Toussaint; O Imventarza; T E Starzl
Journal:  Transplant Proc       Date:  1991-02       Impact factor: 1.066

4.  Cyclosporine A reduces dendritic outgrowth of neuroblasts in the subgranular zone of the dentate gyrus in C57BL/6 mice.

Authors:  In Koo Hwang; Sun Shin Yi; Jae Hoon Shin; Ki-Yeon Yoo; Jung Hoon Choi; Choong Hyun Lee; Je Kyung Seong; Yeo Sung Yoon; Jeong Ho Park; Moo-Ho Won
Journal:  Neurochem Res       Date:  2009-10-25       Impact factor: 3.996

5.  Effects of cyclosporin A on the endocrine pancreas of the rat. Morphological and immunohistochemical studies.

Authors:  R Jablenska; V Ogneva; P Petkov
Journal:  Acta Diabetol Lat       Date:  1989 Jan-Mar

6.  The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model.

Authors:  Yu-Mee Wee; Monica Young Choi; Choong-Hoon Kang; Yang-Hee Kim; Jin-Hee Kim; Sang-Kyou Lee; Seung-Young Yu; Song-Cheol Kim; Duck-Jong Han
Journal:  Mol Med       Date:  2010-04-30       Impact factor: 6.354

7.  Reversibility of the acute toxic effect of cyclosporin A on pancreatic B cells of Wistar rats.

Authors:  H J Hahn; A Dunger; F Laube; W Besch; E Radloff; C Kauert; G Kotzke
Journal:  Diabetologia       Date:  1986-08       Impact factor: 10.122

8.  Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro.

Authors:  I H Waschulewski; D V Hall; H F Kern; J M Edwardson
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

9.  Consequences of systemic venous drainage and denervation of heterotopic pancreatic transplants for insulin/C-peptide profiles in the basal state and after oral glucose.

Authors:  M Nauck; M Büsing; E G Siegel; J Talartschik; A Baartz; T Baartz; U T Hopt; H D Becker; W Creutzfeldt
Journal:  Diabetologia       Date:  1991-08       Impact factor: 10.122

10.  Cyclosporin A-induced nephrotoxicity in the rat: relationship to increased plasma renin activity.

Authors:  F T McAuley; J G Simpson; A W Thomson; P H Whiting
Journal:  Agents Actions       Date:  1987-06
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