Literature DB >> 6388014

Immunocytochemical localization of albumin and factor XIII in thin cryo sections of human blood platelets.

J J Sixma, A van den Berg, M Schiphorst, H J Geuze, J McDonagh.   

Abstract

Albumin and factor XIII alpha 2 were localized in human blood platelets by immunofluorescence and protein A-colloidal gold immuno-electron microscopy using thin and ultrathin cryosections of mildly fixed human blood platelets. Albumin was found in alpha-granules, co-distributing with beta-thromboglobulin in double label experiments. In platelets directly fixed in plasma, without previous washing, albumin was also localized on the plasma membrane and in the surface connecting system. Factor XIII alpha 2 was localized diffusely through the entire cytoplasmic matrix.

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Year:  1984        PMID: 6388014

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN: 0340-6245            Impact factor:   5.249


  15 in total

1.  Immunoelectron-microscopic studies of human platelet thrombospondin, von Willebrand factor, and fibrinogen redistribution during clot formation.

Authors:  S C Watkins; V Raso; H S Slayter
Journal:  Histochem J       Date:  1990-09

2.  In vivo defibrination results in markedly decreased amounts of fibrinogen in rat megakaryocytes and platelets.

Authors:  P J Handagama; M A Shuman; D F Bainton
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

3.  Plasma membrane GPIIb/IIIa. Evidence for a cycling receptor pool.

Authors:  J D Wencel-Drake
Journal:  Am J Pathol       Date:  1990-01       Impact factor: 4.307

4.  Reversible activation of cellular factor XIII by calcium.

Authors:  Gunhild Klarskov Kristiansen; Mette Dahl Andersen
Journal:  J Biol Chem       Date:  2011-01-18       Impact factor: 5.157

5.  Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface.

Authors:  J P Rosa; J N George; D F Bainton; A T Nurden; J P Caen; R P McEver
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

6.  Immunoglobulin G is a platelet alpha granule-secreted protein.

Authors:  J N George; S Saucerman; S P Levine; L K Knieriem; D F Bainton
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808

7.  Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses.

Authors:  J D Wencel-Drake; E F Plow; T J Kunicki; V L Woods; D M Keller; M H Ginsberg
Journal:  Am J Pathol       Date:  1986-08       Impact factor: 4.307

8.  Characterization of cDNA coding for human factor XIIIa.

Authors:  U Grundmann; E Amann; G Zettlmeissl; H A Küpper
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

9.  Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules.

Authors:  P J Handagama; M A Shuman; D F Bainton
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

10.  Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome.

Authors:  C W Jackson; N K Hutson; S A Steward; N Saito; E M Cramer
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

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