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Literature DB >> 6387399

Isolation and characterization of spontaneous srl-recA deletion mutants in Escherichia coli K-12.

Abstract

A method was developed for the isolation of spontaneous mutants of Escherichia coli K-12 with deletions extending from the srl operon to the adjacent recA gene. The srl-recA deletion mutants were extremely sensitive to dNA-damaging agents; unable to support growth of the feckless red gam mutant lambda bio11; and recombination-deficient in transduction and in conjugation. They therefore resembled recA point mutants such as recA13. The existence of these recA deletion mutants shows that the recA gene is not essential for viability.

Entities: Species

Mesh：

Substances：
Rec A Recombinases

Year: 1984 PMID： 6387399 DOI： 10.1007/bf00328071

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

32 in total

1. Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacI gene of Escherichia coli.

Authors: P J Farabaugh; U Schmeissner; M Hofer; J H Miller
Journal: J Mol Biol Date: 1978-12-25 Impact factor: 5.469

2. Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.

Authors: K C Smith; D H Meun
Journal: J Mol Biol Date: 1970-08 Impact factor: 5.469

3. Formation of merodiploids in matings with a class of Rec- recipient strains of Escherichia coli K12.

Authors: B Low
Journal: Proc Natl Acad Sci U S A Date: 1968-05 Impact factor: 11.205

4. The beginning of a genetic analysis of recombination proficiency.

Authors: A J Clark
Journal: J Cell Physiol Date: 1967-10 Impact factor: 6.384

5. Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping.

Authors: J Lengeler
Journal: J Bacteriol Date: 1975-10 Impact factor: 3.490

6. Effect of mutations in deoxyribonucleic acid repair pathways on the sensitivity of Escherichia coli K-12 strains to nitrofurantoin.

Authors: S T Jenkins; P M Bennett
Journal: J Bacteriol Date: 1976-03 Impact factor: 3.490

Isolation and characterization of spontaneous srl-recA deletion mutants in Escherichia coli K-12.

1. Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacI gene of Escherichia coli.

2. Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.

3. Formation of merodiploids in matings with a class of Rec- recipient strains of Escherichia coli K12.

4. The beginning of a genetic analysis of recombination proficiency.

5. Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping.

6. Effect of mutations in deoxyribonucleic acid repair pathways on the sensitivity of Escherichia coli K-12 strains to nitrofurantoin.

Review 7. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

8. Genetic analysis of the RecE pathway of genetic recombination in Escherichia coli K-12.

9. Cloned truncated recA genes in E. coli II. Effects of truncated gene products on in vivo recA+ protein activity.

10. Organization of the recA gene of Escherichia coli.

1. The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli.