Literature DB >> 6386794

Attention deficit disorder and the effect of methylphenidate on attention, behavioral, and cardiovascular functioning.

R T Brown, M E Wynne, L W Slimmer.   

Abstract

The effect of a 0.3 mg/kg dose of methylphenidate on attentional, behavioral, and cardiovascular measures in boys with attention deficit disorder (ADD) was examined. The results of double-blind clinical trials demonstrated a significant improvement in sustained attention and impulse control, as well as in ratings of social behavior by both teachers and parents. Consistent with previous research, cardiovascular functioning did not significantly increase as a function of methylphenidate. Due to the large intraindividual variability in cardiovascular response, careful monitoring of each patient's response is recommended.

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Year:  1984        PMID： 6386794

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  4 in total

1.  Chronic methylphenidate administration alters antioxidant defenses and butyrylcholinesterase activity in blood of juvenile rats.

Authors:  Felipe Schmitz; Emilene Barros da Silva Scherer; Maira Jaqueline da Cunha; Aline Andrea da Cunha; Daniela Delwing Lima; Débora Delwing; Carlos Alexandre Netto; Angela Terezinha de Souza Wyse
Journal:  Mol Cell Biochem       Date:  2011-10-20       Impact factor: 3.396

2.  Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects.

Authors:  Leanna Kalinowski; Carly Connor; Rathini Somanesan; Emily Carias; Kaleigh Richer; Lauren Smith; Connor Martin; Macauley Mackintosh; Daniel Popoola; Michael Hadjiargyrou; David E Komatsu; Panayotis K Thanos
Journal:  Dev Psychobiol       Date:  2019-08-27       Impact factor: 3.038

3.  Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma.

Authors:  Nora D Volkow; Gene-Jack Wang; Joanna S Fowler; Patricia E Molina; Jean Logan; S John Gatley; Andrew Gifford; Yu-Shin Ding; Christopher Wong; Naomi R Pappas; Wei Zhu; James M Swanson
Journal:  Psychopharmacology (Berl)       Date:  2003-02-13       Impact factor: 4.530

Review 4.  Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).

Authors:  Ole Jakob Storebø; Erica Ramstad; Helle B Krogh; Trine Danvad Nilausen; Maria Skoog; Mathilde Holmskov; Susanne Rosendal; Camilla Groth; Frederik L Magnusson; Carlos R Moreira-Maia; Donna Gillies; Kirsten Buch Rasmussen; Dorothy Gauci; Morris Zwi; Richard Kirubakaran; Bente Forsbøl; Erik Simonsen; Christian Gluud
Journal:  Cochrane Database Syst Rev       Date:  2015-11-25
  4 in total

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