Effect of human IgM rheumatoid factor on the glomerular site of localization of passively administered immune complexes in mice.

Injections of highly concentrated preparations of human RF into mice temporarily alter the major immediate (24 hr) site of predominant localization of passively administered soluble immune complexes from the glomerular mesangium to the glomerular capillary lumens, probably by increasing the size of the injected immune complexes. It is possible that larger amounts of RF may lead to a state whereby the complexes are more permanently deflected from the loops and mesangium, and continue to protect the glomerulus from the pathological effects of the complexes.