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Literature DB >> 6386499

Dual properties of cultured retinoblastoma cells: immunohistochemical characterization of neuronal and glial markers.

Abstract

The dual properties of two human retinoblastoma cell lines, WERI-Rb1 and Y79, were investigated with immunohistochemistry. Two neuron-specific markers, dopamine-B-hydroxylase (DBH) and tetanus toxin, and an astrocyte-specific marker, the glial fibrillary acid protein (GFAP), were applied for immunohistochemical reactions. With peroxidase-antiperoxidase (PAP) and immunofluorescence techniques, all of the WERI-Rb1 and Y79 cells showed consistently positive results with both neuronal and glial markers. The findings demonstrate that cultured retinoblastoma cells WERI-Rb1 and Y79 have both neuronal and glial properties.

Entities: Disease Gene Species

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Year: 1984 PMID： 6386499 DOI： 10.1016/0014-4835(84)90009-5

Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467

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Cited

13 in total

Review 1. Histogenesis of retinoblastoma.

Authors: J Hungerford
Journal: Br J Ophthalmol Date: 1990-03 Impact factor: 4.638

Review 2. Some recent developments in ophthalmic pathology.

Authors: A Garner
Journal: Br J Ophthalmol Date: 1990-03 Impact factor: 4.638

Review 3. Applications of monoclonal antibodies in the investigation, diagnosis, and treatment of retinoblastoma.

Authors: J F Tarlton; D L Easty
Journal: Br J Ophthalmol Date: 1993-12 Impact factor: 4.638

4. Differentiation of human retinoblastoma in vitro into cell types with characteristics observed in embryonal or mature retina.

Authors: M Tsokos; A P Kyritsis; G J Chader; T J Triche
Journal: Am J Pathol Date: 1986-06 Impact factor: 4.307

10. Neuroblastic differentiation potential of the human retinoblastoma cell lines Y-79 and WERI-Rb1 maintained in an organ culture system. An immunohistochemical, electron microscopic, and biochemical study.

Authors: M M Herman; E Perentes; C D Katsetos; F Darcel; A Frankfurter; V P Collins; L A Donoso; L F Eng; P J Marangos; A F Wiechmann
Journal: Am J Pathol Date: 1989-01 Impact factor: 4.307

Dual properties of cultured retinoblastoma cells: immunohistochemical characterization of neuronal and glial markers.

Review 1. Histogenesis of retinoblastoma.

Review 2. Some recent developments in ophthalmic pathology.

Review 3. Applications of monoclonal antibodies in the investigation, diagnosis, and treatment of retinoblastoma.

4. Differentiation of human retinoblastoma in vitro into cell types with characteristics observed in embryonal or mature retina.

Review 5. Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma.

6. Retinoblastoma: report of a case with minimal retinal involvement but massive anterior segment spread.

7. Immunohistological characterisation of retinoblastoma and related ocular tissue.

8. Effect of polylysine-bound laminin on human retinoblastoma cell lines.

9. Immunohistochemical features of the human retina and retinoblastoma.

10. Neuroblastic differentiation potential of the human retinoblastoma cell lines Y-79 and WERI-Rb1 maintained in an organ culture system. An immunohistochemical, electron microscopic, and biochemical study.