Literature DB >> 6386132

The effect of aculeacin A and papulacandin B on morphology and cell wall ultrastructure in Candida albicans.

J J Bozzola, R J Mehta, L J Nisbet, J R Valenta.   

Abstract

Transmission (TEM) and scanning electron microscopy (SEM) of Candida albicans cultures treated with the cell wall active antibiotics aculeacin A and papulacandin B (10 micrograms/mL) revealed highly distorted, wrinkled, and collapsed cells. Dividing cells failed to separate properly and aggregates of enlarged and elongated forms were often seen. TEM sections revealed thick and layered cell walls in the treated cultures and bud cross walls failed to segregate completely. Approximately 20% of the cells demonstrated complete cell necrosis accompanied with cytoplasmic deterioration, layered and distorted walls, and improperly formed buds and scars.

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Year:  1984        PMID： 6386132     DOI： 10.1139/m84-133

Source DB:  PubMed          Journal:  Can J Microbiol        ISSN： 0008-4166            Impact factor:   2.419


  9 in total

Review 1.  Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

Authors:  M A Ghannoum; L B Rice
Journal:  Clin Microbiol Rev       Date:  1999-10       Impact factor: 26.132

Review 2.  Models of cell differentiation in conidial fungi.

Authors:  G T Cole
Journal:  Microbiol Rev       Date:  1986-06

3.  FsFKS1, the 1,3-beta-glucan synthase from the caspofungin-resistant fungus Fusarium solani.

Authors:  Young-sil Ha; Sarah F Covert; Michelle Momany
Journal:  Eukaryot Cell       Date:  2006-07

Review 4.  Compounds active against cell walls of medically important fungi.

Authors:  R F Hector
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

5.  Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

Authors:  M B Kurtz; C Douglas; J Marrinan; K Nollstadt; J Onishi; S Dreikorn; J Milligan; S Mandala; J Thompson; J M Balkovec
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

6.  Mechanism of action of anticandidal dipeptides containing inhibitors of glucosamine-6-phosphate synthase.

Authors:  S Milewski; R Andruszkiewicz; L Kasprzak; J Mazerski; F Mignini; E Borowski
Journal:  Antimicrob Agents Chemother       Date:  1991-01       Impact factor: 5.191

7.  Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

Authors:  M B Kurtz; I B Heath; J Marrinan; S Dreikorn; J Onishi; C Douglas
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

8.  In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

Authors:  K Bartizal; G Abruzzo; C Trainor; D Krupa; K Nollstadt; D Schmatz; R Schwartz; M Hammond; J Balkovec; F Vanmiddlesworth
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

9.  Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.

Authors:  M B Kurtz; E M Bernard; F F Edwards; J A Marrinan; J Dropinski; C M Douglas; D Armstrong
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  9 in total

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