| Literature DB >> 6385764 |
E Altomare, M A Leo, C S Lieber.
Abstract
In rats fed alcohol chronically, acetaminophen induced severe hepatotoxicity as judged by serum enzyme activities, liver histology, and mortality, whereas in both rats fed alcohol chronically and in their pair-fed controls, acute ethanol administration decreased acetaminophen hepatotoxicity. Since acetaminophen hepatotoxicity is increased in rats fed alcohol chronically and acute ethanol has been shown to inhibit the biotransformation of acetaminophen to reactive metabolite(s) by mixed function oxidation, we postulate that acute ethanol administration decreases acetaminophen-induced hepatotoxicity in rats fed alcohol chronically by inhibiting the enhanced production of toxic metabolites.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6385764 DOI： 10.1111/j.1530-0277.1984.tb05688.x
Source DB: PubMed Journal: Alcohol Clin Exp Res ISSN： 0145-6008 Impact factor: 3.455