Literature DB >> 6383919

Pre-type 1 (insulin-dependent) diabetes: common endocrinological course despite immunological and immunogenetic heterogeneity.

S Srikanta, O P Ganda, R A Jackson, S J Brink, E Fleischnick, E Yunis, C Alper, J S Soeldner, G S Eisenbarth.   

Abstract

In an ongoing prospective study 32 individuals have been evaluated for insulin secretory dynamics, islet cell antibodies and HLA antigens, during the preclinical phase of Type 1 diabetes mellitus. Twenty-four out of the 32 subjects were islet cell antibody-positive. To date, 14 subjects (10 islet cell antibody-positive, four islet cell antibody-negative) have progressed to develop overt diabetes. Several patterns of HLA-DR expression were noted (DR3/DR4, DR3/DR3, DR3/x, DR3/DR1, DR4/x, DR4/DR7, DR5/DR7, DR1/DR7 and DR1/DR2). Irrespective of differences in islet cell antibody status or HLA-DR alleles, pre-diabetic individuals exhibited a similar slow course of progressive beta-cell dysfunction.

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Year:  1984        PMID： 6383919     DOI： 10.1007/bf00275674

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  6 in total

1.  Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus.

Authors:  S Srikanta; O P Ganda; G S Eisenbarth; J S Soeldner
Journal:  N Engl J Med       Date:  1983-02-10       Impact factor: 91.245

2.  Pre-type I diabetes. Linear loss of beta cell response to intravenous glucose.

Authors:  S Srikanta; O P Ganda; R E Gleason; R A Jackson; J S Soeldner; G S Eisenbarth
Journal:  Diabetes       Date:  1984-08       Impact factor: 9.461

3.  Differential sensitivity to beta-cell secretagogues in "early," type I diabetes mellitus.

Authors:  O P Ganda; S Srikanta; S J Brink; M A Morris; R E Gleason; J S Soeldner; G S Eisenbarth
Journal:  Diabetes       Date:  1984-06       Impact factor: 9.461

4.  Evidence for a long prediabetic period in type I (insulin-dependent) diabetes mellitus.

Authors:  A N Gorsuch; K M Spencer; J Lister; J M McNally; B M Dean; G F Bottazzo; A G Cudworth
Journal:  Lancet       Date:  1981 Dec 19-26       Impact factor: 79.321

5.  Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

Authors:  S Bonner-Weir; D F Trent; G C Weir
Journal:  J Clin Invest       Date:  1983-06       Impact factor: 14.808

6.  Type I diabetes mellitus in monozygotic twins: chronic progressive beta cell dysfunction.

Authors:  S Srikanta; O P Ganda; R A Jackson; R E Gleason; A Kaldany; M R Garovoy; E L Milford; C B Carpenter; J S Soeldner; G S Eisenbarth
Journal:  Ann Intern Med       Date:  1983-09       Impact factor: 25.391
  6 in total
  12 in total

Review 1.  Metabolic abnormalities in the pathogenesis of type 1 diabetes.

Authors:  Shuyao Zhang; Clayton E Mathews
Journal:  Curr Diab Rep       Date:  2014       Impact factor: 4.810

Review 2.  Pharmacological approaches to the prevention of autoimmune diabetes.

Authors:  W E Winter; D V House; D Schatz
Journal:  Drugs       Date:  1997-06       Impact factor: 9.546

Review 3.  A la recherche du temps perdu--epilogue to the Minkowski Award lecture 1974.

Authors:  E Cerasi
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

4.  Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients.

Authors:  P Vardi; L Crisa; R A Jackson
Journal:  Diabetologia       Date:  1991-02       Impact factor: 10.122

5.  Glucose-induced insulin response and insulin sensitivity is not related to HLA-type but to age in young siblings of type 1 (insulin-dependent) diabetic patients.

Authors:  F Lindgren; G Dahlquist; S Efendic; E Möller; B Persson; B Thalme; M L Olsson
Journal:  Diabetologia       Date:  1987-09       Impact factor: 10.122

6.  Islet-cell antibodies as predictors of the later development of type 1 (insulin-dependent) diabetes. A study in identical twins.

Authors:  C Johnston; B A Millward; P Hoskins; R D Leslie; G F Bottazzo; D A Pyke
Journal:  Diabetologia       Date:  1989-06       Impact factor: 10.122

7.  Five-year follow-up of islet cell antibodies in type 2 (non-insulin-dependent) diabetes mellitus.

Authors:  L Niskanen; J Karjalainen; H Sarlund; O Siitonen; M Uusitupa
Journal:  Diabetologia       Date:  1991-06       Impact factor: 10.122

8.  Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

Authors:  S Baekkeskov; M Landin; J K Kristensen; S Srikanta; G J Bruining; T Mandrup-Poulsen; C de Beaufort; J S Soeldner; G Eisenbarth; F Lindgren
Journal:  J Clin Invest       Date:  1987-03       Impact factor: 14.808

9.  Relationship between serum insulin autoantibodies, islet cell antibodies and Coxsackie-B4 and mumps virus-specific antibodies at the clinical manifestation of type 1 (insulin-dependent) diabetes.

Authors:  J Karjalainen; M Knip; H Hyöty; P Leinikki; J Ilonen; M L Käär; H K Akerblom
Journal:  Diabetologia       Date:  1988-03       Impact factor: 10.122

10.  Type 1 diabetes pathogenesis - Prevention???

Authors:  C S Muralidhara Krishna; S Srikanta
Journal:  Indian J Endocrinol Metab       Date:  2015-04
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