Literature DB >> 6383869

The effect of phalloidin on insulin secretion from islets of Langerhans isolated from rat pancreas.

J Stutchfield, S L Howell.   

Abstract

Phalloidin, which stabilizes F-actin, has no effect on insulin secretion from intact islets, but penetrates and increases secretion from islets previously made permeable using a high voltage discharge technique. Use of this highly specific drug strongly suggests a role for microfilaments composed of F-actin in the insulin secretory process.

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Year:  1984        PMID： 6383869     DOI： 10.1016/0014-5793(84)80775-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.

Authors:  H C Cable; A el-Mansoury; N G Morgan
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

2.  Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.

Authors:  G Li; E Rungger-Brändle; I Just; J C Jonas; K Aktories; C B Wollheim
Journal:  Mol Biol Cell       Date:  1994-11       Impact factor: 4.138

Review 3.  Insulin secretion: the effector system.

Authors:  S L Howell; M Tyhurst
Journal:  Experientia       Date:  1984-10-15

4.  Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells.

Authors:  A Koffer; P E Tatham; B D Gomperts
Journal:  J Cell Biol       Date:  1990-09       Impact factor: 10.539

Review 5.  Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells.

Authors:  Michael A Kalwat; Debbie C Thurmond
Journal:  Exp Mol Med       Date:  2013-08-23       Impact factor: 8.718
  5 in total

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