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Literature DB >> 6383381

Production of an insulin-like growth factor by osteosarcoma.

J Blatt, C White, S Dienes, H Friedman, T P Foley.

Abstract

To test the possibility that osteosarcoma cells produce their own growth factors, we measured levels of insulin and somatomedin C (SMC), an insulin-like growth factor, in culture media of two cell lines derived from patients with that disease. SMC but not insulin levels increased three- to ten-fold over a period of 7 days paralleling the increases in cell number. Production of SMC was inhibited by cycloheximide.

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Year: 1984 PMID： 6383381 DOI： 10.1016/0006-291x(84)90423-6

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

11 in total

1. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

Authors: J Trojan; B K Blossey; T R Johnson; S D Rudin; M Tykocinski; J Ilan; J Ilan
Journal: Proc Natl Acad Sci U S A Date: 1992-06-01 Impact factor: 11.205

2. Identification of a novel transcription unit in the human insulin-like growth factor-II gene.

Authors: K Ikejiri; T Wasada; K Haruki; N Hizuka; Y Hirata; M Yamamoto
Journal: Biochem J Date: 1991-12-01 Impact factor: 3.857

Review 3. Insulin-like growth factors in central nervous system tumors.

Authors: R P Glick; T Lichtor; T G Unterman
Journal: J Neurooncol Date: 1997-12 Impact factor: 4.130

4. Parental allele specific methylation of the human insulin-like growth factor II gene and Beckwith-Wiedemann syndrome.

Authors: H Schneid; D Seurin; M P Vazquez; M Gourmelen; S Cabrol; Y Le Bouc
Journal: J Med Genet Date: 1993-05 Impact factor: 6.318

5. Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: significant correlation with malignant potential.

Authors: Lill-Tove R Busund; Kim T Ow; Pamela Russell; Philip J Crowe; Jia-Lin Yang
Journal: Virchows Arch Date: 2003-12-12 Impact factor: 4.064

Production of an insulin-like growth factor by osteosarcoma.

1. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

2. Identification of a novel transcription unit in the human insulin-like growth factor-II gene.

Review 3. Insulin-like growth factors in central nervous system tumors.

4. Parental allele specific methylation of the human insulin-like growth factor II gene and Beckwith-Wiedemann syndrome.

5. Expression of insulin-like growth factor mitogenic signals in adult soft-tissue sarcomas: significant correlation with malignant potential.

6. Somatomedins in tumour cyst fluid, cerebrospinal fluid, and tumour cytosol in patients with glial tumours.

Review 7. Autocrine growth factors and solid tumor malignancy.

8. Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

Review 9. Insulin-like growth factors and cancer.

10. Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.