Literature DB >> 6383352

Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats.

R A Challis, L Budohoski, B McManus, E A Newsholme.   

Abstract

The decreased sensitivity of glycolysis to insulin seen in isolated soleus muscles from genetically obese Zucker rats was abolished by addition of the adenosine-receptor antagonist 8-phenyltheophylline to the incubation medium; 8-phenyltheophylline had no effect on the sensitivity of glycogen synthesis to insulin. These findings suggest that changes in the sensitivity of glucose utilization by muscles of genetically obese rats may be explained, in part, by a modification in either the concentration of adenosine or the affinity of adenosine receptors in skeletal muscle.

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Year:  1984        PMID： 6383352      PMCID： PMC1144125          DOI： 10.1042/bj2210915

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

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Authors:  F Assimacopoulos-Jeannet; B Jeanrenaud
Journal:  Clin Endocrinol Metab       Date:  1976-07

Review 2.  Insulin and obesity.

Authors:  B Jeanrenaud
Journal:  Diabetologia       Date:  1979-09       Impact factor: 10.122

Review 3.  The control of the metabolism and the hormonal role of adenosine.

Authors:  J R Arch; E A Newsholme
Journal:  Essays Biochem       Date:  1978       Impact factor: 8.000

4.  Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts.

Authors:  R F Bruns
Journal:  Biochem Pharmacol       Date:  1981-02-15       Impact factor: 5.858

5.  Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes.

Authors:  M Kobayashi; J M Olefsky
Journal:  Am J Physiol       Date:  1978-07

6.  Subclasses of external adenosine receptors.

Authors:  C Londos; D M Cooper; J Wolff
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

7.  Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

Authors:  S W Cushman; L J Wardzala
Journal:  J Biol Chem       Date:  1980-05-25       Impact factor: 5.157

8.  Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat.

Authors:  L Budohoski; R A Challiss; B McManus; E A Newsholme
Journal:  FEBS Lett       Date:  1984-02-13       Impact factor: 4.124

9.  Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites.

Authors:  M Crettaz; M Prentki; D Zaninetti; B Jeanrenaud
Journal:  Biochem J       Date:  1980-02-15       Impact factor: 3.857

10.  Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.

Authors:  L J Wardzala; B Jeanrenaud
Journal:  J Biol Chem       Date:  1981-07-25       Impact factor: 5.157
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  12 in total

1.  Adenosine deaminase and porcine meat quality. II. Effects of adenosine analogues on plasma free fatty acids, glucose and lactate in pigs representing high and low adenosine deaminase red cell activity.

Authors:  J F Hyldgaard-Jensen
Journal:  Acta Vet Scand       Date:  1990       Impact factor: 1.695

2.  Effects of prolonged elevation of plasma adrenaline concentration in vivo on insulin-sensitivity in soleus muscle of the rat.

Authors:  L Budohoski; R A Challiss; A Dubaniewicz; H Kaciuba-Usciłko; B Leighton; F J Lozeman; K Nazar; E A Newsholme; S Porta
Journal:  Biochem J       Date:  1987-06-15       Impact factor: 3.857

3.  Effect of various types of acute exercise and exercise training on the insulin sensitivity of rat soleus muscle measured in vitro.

Authors:  J Langfort; L Budohoski; E A Newsholme
Journal:  Pflugers Arch       Date:  1988-07       Impact factor: 3.657

Review 4.  Regulation of leukocyte function by adenosine receptors.

Authors:  Joel Linden
Journal:  Adv Pharmacol       Date:  2011

5.  Effects of the beta-adrenoceptor agonist isoprenaline on insulin-sensitivity in soleus muscle of the rat.

Authors:  R A Challiss; F J Lozeman; B Leighton; E A Newsholme
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

6.  Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism.

Authors:  Milka Koupenova; Katya Ravid
Journal:  J Cell Physiol       Date:  2013-03-04       Impact factor: 6.384

7.  Effects of hypothyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat.

Authors:  G D Dimitriadis; B Leighton; M Parry-Billings; D West; E A Newsholme
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

8.  Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonist.

Authors:  L Budohoski; R A Challiss; G J Cooney; B McManus; E A Newsholme
Journal:  Biochem J       Date:  1984-11-15       Impact factor: 3.857

Review 9.  The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes.

Authors:  Joanne S J Chia; Jennifer L McRae; Peter J Cowan; Karen M Dwyer
Journal:  J Biomed Biotechnol       Date:  2012-10-14

10.  Impact of Adenosine Analogue, Adenosine-5'-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells.

Authors:  Mansour Haddad
Journal:  Biomed Res Int       Date:  2021-06-26       Impact factor: 3.411
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