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Literature DB >> 6383225

Tranexamic acid in the prevention of periventricular haemorrhage.

Abstract

Increased fibrinolytic activity in the ganglionic eminence of the preterm human brain has been proposed as a factor in the aetiology of periventricular haemorrhage. The effect of tranexamic acid in preventing periventricular haemorrhage was evaluated in 100 infants in a double blind, randomised controlled trial. Haemorrhages developed in 22 infants who received tranexamic acid and in 20 of those who received placebo. A significant reduction in fibrin degradation products in treated infants was seen. Our study suggests that excessive fibrinolytic activity is not an important factor in the aetiology of periventricular haemorrhage and that treatment with tranexamic acid will not prevent its occurrence.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6383225 PMCID： PMC1628624 DOI： 10.1136/adc.59.8.719

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

17 in total

1. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.

Authors: L A Papile; J Burstein; R Burstein; H Koffler
Journal: J Pediatr Date: 1978-04 Impact factor: 4.406

2. Prolonged antifibrinolysis: an effective non-surgical treatment for ruptured intracranial aneurysms?

Authors: R S Maurice-Williams
Journal: Br Med J Date: 1978-04-15

3. Tranexamic acid in upper gastrointestinal haemorrhage.

Authors: F Cormack; R R Chakrabarti; A J Jouhar; G R Fearnley
Journal: Lancet Date: 1973-06-02 Impact factor: 79.321

4. Ultrasound examination of neonatal heads.

Authors: R W Cooke
Journal: Lancet Date: 1979-07-07 Impact factor: 79.321

Review 5. Neonatal intraventricular hemorrhage.

Authors: J J Volpe
Journal: N Engl J Med Date: 1981-04-09 Impact factor: 91.245

6. Prevention of intraventricular haemorrhage in preterm infants by phenobarbitone. A controlled trial.

Authors: S M Donn; D W Roloff; G W Goldstein
Journal: Lancet Date: 1981-08-01 Impact factor: 79.321

7. Origin of intraventricular haemorrhage in the preterm infant.

Authors: G Hambleton; J S Wigglesworth
Journal: Arch Dis Child Date: 1976-09 Impact factor: 3.791

8. Phenobarbitone for prevention of periventricular haemorrhage in very low birth-weight infants. A randomised double-blind trial.

Authors: A Whitelaw; M Placzek; L Dubowitz; S Lary; M Levene
Journal: Lancet Date: 1983-11-19 Impact factor: 79.321

Tranexamic acid in the prevention of periventricular haemorrhage.

1. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.

2. Prolonged antifibrinolysis: an effective non-surgical treatment for ruptured intracranial aneurysms?

3. Tranexamic acid in upper gastrointestinal haemorrhage.

4. Ultrasound examination of neonatal heads.

Review 5. Neonatal intraventricular hemorrhage.

6. Prevention of intraventricular haemorrhage in preterm infants by phenobarbitone. A controlled trial.

7. Origin of intraventricular haemorrhage in the preterm infant.

8. Phenobarbitone for prevention of periventricular haemorrhage in very low birth-weight infants. A randomised double-blind trial.

9. Antifibrinolysis with tranexamic acid in aneurysmal subarachnoid hemorrhage: a consecutive controlled clinical trial.

10. Tranexamic acid in subarachnoid hemorrhage. A double-blind study.

1. Prevention of neonatal intracerebral hemorrhage.

2. Endogenous fibrinolysis in neonatal cerebrospinal fluid.