Atropine in asystole: human studies.

Current research supporting the use of atropine for asystole is limited. Reported in the literature are the cases of 26 patients who presented with a rhythm of asystole. Of these, only eight were clearly in refractory asystole after epinephrine and sodium bicarbonate, only seven were prehospital patients, and only two were delineated as being intubated. Despite such limited data, atropine has been advocated for asystole, and use of the drug is included in the recommendations of the American Heart Association. We undertook a retrospective review of our prehospital experience with refractory asystole for a four-year period from January 1979 to December 1982. All patients with trauma or poisoning and all pediatric arrests were excluded. All patients who received calcium chloride during resuscitation also were excluded. One hundred seventy patients presented in cardiorespiratory arrest with an initial rhythm of asystole. Of these, 84 remained in refractory asystole after receiving epinephrine and sodium bicarbonate. Forty-three patients in this group received atropine. The successful resuscitation rate in the atropine group was 14% (6/43), while in the control group it was 0% (0/41) (P less than .04). A successful resuscitation was defined as conveyance of a patient with a rhythm and a pulse to an emergency department. Patients were compared for age, sex, witnessing of arrest, cardiac history, and cardiac drugs. No other significant differences were noted between groups. No patient who received atropine for refractory asystole was discharged alive.