Molecular events leading to fertilization--a review.

Fertilization consists of a sequence of complex events which culminates in the fusion of the genetic information provided by two parent cells, thus leading to the formation of a new individuum. The male gamete develops in the testis, acquires forward motility and fertilizing capacity during maturation in the epididymis, and after capacitation undergoes the acrosome reaction in the female reproductive tract. The female gamete matures in the cyclically developing follicles and, by the time of ovulation, reaches a quiescent stage at metaphase II of meiosis. Gamete fusion occurs in the distal tube, and involves a series of modifications on the egg surface and its investments, intended to protect the developing embryo from polyspermy.