Literature DB >> 6382607

Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain.

T Maciag, T Mehlman, R Friesel, A B Schreiber.   

Abstract

Endothelial cell growth factor (ECGF), an anionic polypeptide mitogen, binds to immobilized heparin. The interaction between the acidic polypeptide and the anionic carbohydrate suggests a mechanism that is independent of ion exchange. Monoclonal antibodies to purified bovine ECGF inhibited the biological activity of ECGF in crude preparations of bovine brain. These data indicate that ECGF is the principal mitogen for endothelial cells from bovine brain, that heparin affinity chromatography may be used to purify and concentrate ECGF, and that the affinity of ECGF for heparin may have structural and perhaps biological significance.

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Year:  1984        PMID： 6382607     DOI： 10.1126/science.6382607

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  92 in total

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Review 7.  Modes of FGF release in vivo and in vitro.

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Review 9.  Protein factors which regulate cell motility.

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10.  Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis.

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