Use of naltrexone to extinguish opioid-conditioned responses.

Opioid use generates many conditioned responses associated with the sights, sounds, smells, and rituals experienced during addiction. Environmental stimuli alone can provoke withdrawal symptoms and contribute to relapses in treated patients. The use of naltrexone in a program designed to progressively extinguish conditioned drug responses is described. Since naltrexone effectively blocks opiate effects at the receptor level, heroin injections produce no euphoria. Unreinforced self-injections diminish the responses learned during the period of drug abuse and protect the patient from rapid readdiction. Patients are confronted with a hierarchical set of drug-related stimuli and taught a muscular relaxation procedure to relieve arousal and discomfort. The continued administration of naltrexone, the self-induced relaxation response, and the repeated presentation of drug-related stimuli result in the eventual diminution or extinction of the arousal properties of the imagery and environmental stimuli associated with addiction.