| Literature DB >> 6380963 |
G F Rush, J H Smith, J F Newton, J B Hook.
Abstract
Renal xenobiotic metabolism can result in production of electrophiles or free radicals that may covalently bind macromolecules or initiate lipid peroxidation. The mechanisms of renal xenobiotic metabolism may vary in different anatomical regions. Kidney cortex contains a cytochrome P-450 system while medulla contains a prostaglandin endoperoxidase. Recently cysteine conjugated-lyase has been implicated in production of reactive intermediates. Metabolic activation may be amplified by accumulation of xenobiotics within renal cells due to tubular concentrating and/or secretory mechanisms. Additionally, renal xenobiotic detoxicification can occur by conjugation with glucuronide, sulfate or glutathione.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6380963 DOI： 10.3109/10408448409034079
Source DB: PubMed Journal: Crit Rev Toxicol ISSN： 1040-8444 Impact factor: 5.635