Literature DB >> 6379759

Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion.

J J Holst, J Fahrenkrug, S Knuhtsen, S L Jensen, S S Poulsen, O V Nielsen.   

Abstract

Vasoactive intestinal polypeptide (VIP) in the pig pancreas is localized to nerves, many of which travel along the pancreatic ducts. VIP stimulates pancreatic fluid and bicarbonate secretion like secretin. Electrical vagal stimulation in the pig causes an atropine-resistant profuse secretion of bicarbonate-rich pancreatic juice. In an isolated perfused preparation of the pig pancreas with intact vagal nerve supply, electrical vagal stimulation caused an atropine-resistant release of VIP, which accurately parallelled the exocrine secretion of juice and bicarbonate. Perfusion of the pancreas with a potent VIP-antiserum inhibited the effect of vagal stimulation on the exocrine secretion. It is concluded, that VIP is responsible for (at least part of) the neurally controlled fluid and bicarbonate secretion from the pig pancreas.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6379759     DOI： 10.1016/0167-0115(84)90066-1

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  11 in total

Review 1.  Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

Authors:  Min Goo Lee; Ehud Ohana; Hyun Woo Park; Dongki Yang; Shmuel Muallem
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

2.  Neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), but not galanin, are autonomic cotransmitters in the porcine pancreas.

Authors:  T Messell; B E Dunning; S Sheikh; J J Holst
Journal:  Int J Pancreatol       Date:  1991-10

Review 3.  Neural regulation of the endocrine pancreas.

Authors:  F C Brunicardi; D M Shavelle; D K Andersen
Journal:  Int J Pancreatol       Date:  1995-12

4.  Peptidergic hormones and neuropeptides, and aminergic neurotransmitters of the pancreatic islets of the Houbara bustard (Chlamydotis undulata).

Authors:  E P Mensah-Brown; T A Bailey; D J Pallot; A Garner
Journal:  J Anat       Date:  2000-02       Impact factor: 2.610

Review 5.  Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion.

Authors:  B Ahrén; G J Taborsky; D Porte
Journal:  Diabetologia       Date:  1986-12       Impact factor: 10.122

6.  Vasoactive intestinal polypeptide-augmented insulin release: actions on ionic fluxes and electrical activity of mouse islets.

Authors:  M A Wahl; S G Straub; H P Ammon
Journal:  Diabetologia       Date:  1993-10       Impact factor: 10.122

7.  Extra-pancreatic vipoma.

Authors:  Franz R Apodaca-Torrez; Marcello Triviño; Edson José Lobo; Alberto Goldenberg; Tarcísio Triviño
Journal:  Arq Bras Cir Dig       Date:  2014 Jul-Sep

8.  Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.

Authors:  J Barrett; J J McDougall; J D Morrison
Journal:  J Physiol       Date:  1993-09       Impact factor: 5.182

Review 9.  Pancreatic VIPomas: subject review and one institutional experience.

Authors:  Amir A Ghaferi; Karen A Chojnacki; William D Long; John L Cameron; Charles J Yeo
Journal:  J Gastrointest Surg       Date:  2008-02       Impact factor: 3.452

10.  Expression and localization of VPAC1, the major receptor of vasoactive intestinal peptide along the length of the intestine.

Authors:  Dulari Jayawardena; Grace Guzman; Ravinder K Gill; Waddah A Alrefai; Hayat Onyuksel; Pradeep K Dudeja
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2017-04-06       Impact factor: 4.052
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.