Literature DB >> 637975

99mTc-imidodiphosphonate: a superior radio-pharmaceutical for in vivo positive myocardial infarct imaging. I: Experimental data.

P J Ell, R Langford, P Pearce, D Lui, A T Elliott, N Woolf, E S Williams.   

Abstract

99mTc-Imidodiphosphonate (99mTc-IDP) was investigated as an agent for nuclear medicine imaging of acute myocardial infarctions. For this purpose a suitable animal model was found. After coronary artery ligation reproducible myocardial infarcts were obtained with 80% of surviving animals. Scans of the myocardial infarcts were recorded with a high resolution gamma camera and good quality images were obtained. 99mTc-IDP ratios for normal and infarcted tissue were calculated and compared with similar data available from other 99mTc-labelled phosphates. With an infarct/normal ratio of 21:1, 99mTc-IDP is so far the best radiopharmaceutical for nuclear medicine imaging of necrosed heart muscle. Images of the myocardial infarcts have been recorded as early as 6 hours after infarction.

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Year:  1978        PMID： 637975      PMCID： PMC481986          DOI： 10.1136/hrt.40.3.226

Source DB:  PubMed          Journal:  Br Heart J        ISSN： 0007-0769


  8 in total

1.  Technetium-99m labelled imidodiphosphate: an improved bone-scanning radiopharmaceutical.

Authors:  K R Brody; P Hosain; R P Spencer; F Hosain; H N Wagner
Journal:  Br J Radiol       Date:  1976-03       Impact factor: 3.039

2.  High-quality, high-throughput, early whole-body bone scanning.

Authors:  P J Ell; M A Al-Eid; D Lui; P C Pearce; A T Elliott; N J Brown
Journal:  Nuklearmedizin       Date:  1977-10       Impact factor: 1.379

3.  A new method for radionuclide imaging of myocardial infarcts.

Authors:  F J Bonte; R W Parkey; K D Graham; J Moore; E M Stokely
Journal:  Radiology       Date:  1974-02       Impact factor: 11.105

4.  Noninvasive visualization of acute myocardial infarction in man with thallium-201.

Authors:  F J Wackers; J B Schoot; E B Sokole; G Samson; G J Niftrik; K I Lie; D Durrer; H J Wellens
Journal:  Br Heart J       Date:  1975-07

5.  Myocardial imaging in the noninvasive evaluation of patients with suspected ischemic heart disease.

Authors:  B Pitt; H W Strauss
Journal:  Am J Cardiol       Date:  1976-04       Impact factor: 2.778

6.  Histopathology of early myocardial infarcts. A new approach.

Authors:  B Bouchardy; G Majno
Journal:  Am J Pathol       Date:  1974-02       Impact factor: 4.307

7.  Myocardial uptake (rabbit) of six 99mTc-tagged pharmaceuticals and 85Sr after vasopressin-induced necrosis.

Authors:  Z D Grossman; A B Foster; J G McAfee; R Richardson; G Subramanian; B Markarian; G Gagne; D Bassano
Journal:  J Nucl Med       Date:  1977-01       Impact factor: 10.057

Review 8.  Myocardial infarct imaging with technetium-99m phosphates.

Authors:  R W Parkey; F J Bonte; L M Buja; E M Stokely; J T Willerson
Journal:  Semin Nucl Med       Date:  1977-01       Impact factor: 4.446
  8 in total
  2 in total

Review 1.  An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications.

Authors:  Marlein Miranda Cona; Peter de Witte; Alfons Verbruggen; Yicheng Ni
Journal:  World J Methodol       Date:  2013-12-26

2.  99mTc-imidodiphosphonate: a superior radio-pharmaceutical for in vivo positive myocardial infarct imaging. II: Clinical data.

Authors:  S P Joseph; P J Ell; P Ross; R Donaldson; A T Elliott; N J Brown; E S Williams
Journal:  Br Heart J       Date:  1978-03
  2 in total

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