Literature DB >> 6379629

Cimetidine therapy does not prevent rebleeding from peptic ulceration.

D L Carr-Locke, D Taverner, A C Wicks.   

Abstract

One-hundred and five patients admitted to hospital with symptoms of acute upper gastrointestinal haemorrhage shown at endoscopy to be due to peptic ulceration were entered into a prospective double-blind controlled trial of cimetidine versus placebo therapy. The trial therapy was commenced within 12 hr of admission and continued for 7 days. Cimetidine therapy made no difference to the transfusion requirements, rebleeding rate or number of operations performed in patients with either gastric or duodenal ulcers, nor was it of benefit in patients aged over 65 years of age.

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Year:  1984        PMID： 6379629      PMCID： PMC2417896          DOI： 10.1136/pgmj.60.704.400

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  9 in total

1.  Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage.

Authors:  F W Green; M M Kaplan; L E Curtis; P H Levine
Journal:  Gastroenterology       Date:  1978-01       Impact factor: 22.682

2.  Cimetidine in bleeding peptic ulcer.

Authors:  A F Macklon; S H Roberts; O James
Journal:  Lancet       Date:  1979-11-24       Impact factor: 79.321

3.  Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Authors:  W L Burland; W A Duncan; T Hesselbo; J G Mills; P C Sharpe; S J Haggie; J H Wyllie
Journal:  Br J Clin Pharmacol       Date:  1975-12       Impact factor: 4.335

4.  Controlled trial of cimetidine in acute upper gastrointestinal bleeding.

Authors:  R G Pickard; I Sanderson; M South; J S Kirkham; T C Northfield
Journal:  Br Med J       Date:  1979-03-10

5.  Cimetidine in bleeding peptic ulcer.

Authors:  A M Hoare; G V Bradby; C F Hawkins; J Y Kang; P W Dykes
Journal:  Lancet       Date:  1979-09-29       Impact factor: 79.321

6.  Prevention of sepsis-induced gastric lesions in dogs by cimetidine via inhibition of gastric secretion and by prostaglandin via cytoprotection.

Authors:  P Odonkor; C Mowat; H S Himal
Journal:  Gastroenterology       Date:  1981-02       Impact factor: 22.682

7.  Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial.

Authors:  H E Carstensen; S Bülow; O H Hansen; B H Jakobsen; T Krarup; T Pedersen; D Raahave; L B Svendsen; O Backer
Journal:  Scand J Gastroenterol       Date:  1980       Impact factor: 2.423

8.  Controlled trial of cimetidine in upper gastrointestinal haemorrhage.

Authors:  S J La Brooy; J J Misiewicz; J Edwards; P M Smith; S J Haggie; L Libman; M Sarner; J H Wyllie; J Croker; P Cotton
Journal:  Gut       Date:  1979-10       Impact factor: 23.059

9.  Further haemorrhage after admission to hospital for gastrointestinal haemorrhage.

Authors:  P F Jones; S J Johnston; A B McEwan; J Kyle; C D Needham
Journal:  Br Med J       Date:  1973-09-29
  9 in total
  1 in total

1.  Evidence-based clinical practice guidelines for peptic ulcer disease 2015.

Authors:  Kiichi Satoh; Junji Yoshino; Taiji Akamatsu; Toshiyuki Itoh; Mototsugu Kato; Tomoari Kamada; Atsushi Takagi; Toshimi Chiba; Sachiyo Nomura; Yuji Mizokami; Kazunari Murakami; Choitsu Sakamoto; Hideyuki Hiraishi; Masao Ichinose; Naomi Uemura; Hidemi Goto; Takashi Joh; Hiroto Miwa; Kentaro Sugano; Tooru Shimosegawa
Journal:  J Gastroenterol       Date:  2016-02-15       Impact factor: 7.527
  1 in total

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