Literature DB >> 637886

Therapeutic studies in NZB/NZW mice. VI. Age-dependent effects of concanavalin A stimulated spleen cell supernate.

A D Steinberg, R Krakauer, J L Reinertsen, L W Klassen, D Ilfeld, J P Reeves, G W Williams, T Antonovych.   

Abstract

Spleen cells from normal mice were cultured with Concanavalin A to produce an immunosuppressive supernate. This supernate was used to treat the lupus-like autoimmune disease of NZB/NZW mice. Such treated mice lived significantly longer than did controls, but only if treatment was initiated early in the course of the illness.

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Year:  1978        PMID: 637886     DOI: 10.1002/art.1780210205

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN: 0004-3591


  3 in total

Review 1.  Autoimmune diseases: immunopathology and etiopathogenesis.

Authors:  A N Theofilopoulos; F J Dixon
Journal:  Am J Pathol       Date:  1982-09       Impact factor: 4.307

2.  The effects of CP 17193, an immunosuppressive pyrazaloquinoline, on the development of spontaneous lupus disease in NZBW F1 hybrid mice.

Authors:  R V Bundick; R P Eady
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

3.  Hydrocortisone reverses the suppression of immunoglobulin synthesis by concanavalin A-activated spleen cell supernatants.

Authors:  D Ilfeld; R S Krakauer
Journal:  Clin Exp Immunol       Date:  1982-04       Impact factor: 4.330

  3 in total

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