Literature DB >> 6378767

Defective regulation of the immune response to tetanus toxoid in Hashimoto's disease.

J Fawcett, C Hutton, S M Mclachlan, F Clark, B Rees Smith.   

Abstract

The humoral immune response to tetanus toxoid has been studied in patients with Hashimoto's disease. Although the magnitude of the response was similar to that observed in normal subjects, the Hashimoto patients demonstrated an inability to regulate their levels of tetanus toxoid antibody. This apparent defect in the control of antibody synthesis may be an important factor in both the initiation and perpetuation of autoimmune thyroid disease.

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Year:  1984        PMID： 6378767      PMCID： PMC1454492     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  7 in total

1.  THE ANTIBODY RESPONSE TO TETANUS TOXOID IN PATIENTS WITH AUTO-IMMUNE THYROIDITIS.

Authors:  M BARR; W W BUCHANAN; D DONIACH; I M ROITT
Journal:  Scott Med J       Date:  1964-07       Impact factor: 0.729

2.  Investigations of thyroid antigens reacting with Hashimoto sera; evidence for an antigen other than thyroglobulin.

Authors:  G BELYAVIN; W R TROTTER
Journal:  Lancet       Date:  1959-03-28       Impact factor: 79.321

3.  Persistence of antitoxin levels after tetanus-toxoid inoculation in adults, and effect of a booster dose after various intervals.

Authors:  J M LOONEY; G EDSALL; J IPSEN; W H CHASEN
Journal:  N Engl J Med       Date:  1956-01-05       Impact factor: 91.245

4.  Auto-antibodies in Hashimoto's disease (lymphadenoid goitre).

Authors:  I M ROITT; D DONIACH; P N CAMPBELL; R V HUDSON
Journal:  Lancet       Date:  1956-10-20       Impact factor: 79.321

5.  An enzyme-linked immunoassay for thyroid microsomal antibodies.

Authors:  C W Schardt; S M McLachlan; J Matheson; B R Smith
Journal:  J Immunol Methods       Date:  1982-12-17       Impact factor: 2.303

6.  The IgG subclass distribution of thyroglobulin antibody synthesized in culture.

Authors:  P M Thompson; S M McLachlan; A Parkes; F Clark; D Howel; B Rees Smith
Journal:  Scand J Immunol       Date:  1983-08       Impact factor: 3.487

7.  Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers.

Authors:  W J Yount; M M Dorner; H G Kunkel; E A Kabat
Journal:  J Exp Med       Date:  1968-03-01       Impact factor: 14.307
  7 in total
  2 in total

1.  Endocrine regulation of the immune system.

Authors:  W Kiess; B H Belohradsky
Journal:  Klin Wochenschr       Date:  1986-01-02

2.  The T cell suppressor defect in autoimmune thyroiditis: evidence for a high set 'autoimmunostat'.

Authors:  T F Davies; M Platzer
Journal:  Clin Exp Immunol       Date:  1986-01       Impact factor: 4.330
  2 in total

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