Literature DB >> 6378640

Pharmacokinetic data processed by microcomputer for the formulation of optimal drug dosage form.

J M Aiache, M Turlier, A Tanguy.   

Abstract

Microcomputers have been used in pharmacokinetics for several years, but their use in the area of formulation is a new application. By using appropriate data on the drug, the dosage form required and its mechanism of absorption and clearance, microcomputers can systematize and speed-up formulation, simplify manufacturing processes and, through simulated models and plasma level predictions, reduce the number of bioavailability studies needed.

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Year:  1984        PMID: 6378640     DOI: 10.1007/BF03189611

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN: 0378-7966            Impact factor:   2.441


  9 in total

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Authors:  R G WIEGAND; J D TAYLOR
Journal:  Biochem Pharmacol       Date:  1960-07       Impact factor: 5.858

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Journal:  J Pharmacokinet Biopharm       Date:  1974-12

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Authors:  C C Peck; B B Barrett
Journal:  J Pharmacokinet Biopharm       Date:  1979-10

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Authors:  D Gueurten; F Jaminet
Journal:  Pharm Acta Helv       Date:  1981

6.  A program for non-linear regression analysis to be used on desk-top computers.

Authors:  P Koeppe; C Hamann
Journal:  Comput Programs Biomed       Date:  1980-12

7.  The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

Authors:  S Riegelman; P Collier
Journal:  J Pharmacokinet Biopharm       Date:  1980-10

8.  [Optimization of pharmaceutical formulations by the simplex method using a TI 59 calculator].

Authors:  C Bindschaedler; R Gurny
Journal:  Pharm Acta Helv       Date:  1982

9.  Theoretical formulation of sustained-release dosage forms.

Authors:  J R Robinson; S P Eriksen
Journal:  J Pharm Sci       Date:  1966-11       Impact factor: 3.534

  9 in total
  1 in total

1.  The influence of food on the bioavailability of a slow release theophylline preparation.

Authors:  J J Thebault; J M Aiache; F Mazoyer; J M Cardot
Journal:  Clin Pharmacokinet       Date:  1987-10       Impact factor: 6.447

  1 in total

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