Literature DB >> 6377990

Immunofluorescence studies of renal basement membranes in dogs with spontaneous diabetes.

K Jeraj, J Basgen, R M Hardy, C A Osborne, A F Michael.   

Abstract

Renal tissue from 12 dogs with spontaneous diabetes and 16 control dogs were studied by light, immunofluorescence, and electron microscopies. Significant linear staining for immunoglobulin G and albumin were observed in the glomerular and tubular basement membranes of dogs with spontaneous diabetes--similar to that observed in human diabetes. On immunohistochemical grounds, it would appear that the dog with spontaneous diabetes is an appropriate model of diabetes in persons.

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Year:  1984        PMID: 6377990

Source DB:  PubMed          Journal:  Am J Vet Res        ISSN: 0002-9645            Impact factor:   1.156


  1 in total

1.  Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.

Authors:  Allison L O'Kell; Timothy J Garrett; Clive Wasserfall; Mark A Atkinson
Journal:  Sci Rep       Date:  2017-08-25       Impact factor: 4.379

  1 in total

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