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Literature DB >> 6377287

Hyperkalaemia in diabetes mellitus--potential hazards of coexisting hyporeninaemic hypoaldosteronism.

Abstract

Two patients with insulin-dependent diabetes mellitus (Type I), developed severe, life-threatening hyperkalaemia, the first following treatment with spironolactone, the second during treatment for staphylococcal septicaemia when glucose-induced hyperkalaemia occurred. Investigations demonstrated co-existing hyporeininaemic hypoaldosteronism. Prompt recognition of this combined hormone-deficiency syndrome led to appropriate treatment and recovery. The biochemical features and clinical importance of hyporeninaemic hypoaldosteronism are discussed.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6377287 PMCID： PMC2417866 DOI： 10.1136/pgmj.60.703.370

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

11 in total

1. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism.

Authors: P Szylman; O S Better; C Chaimowitz; A Rosler
Journal: N Engl J Med Date: 1976-02-12 Impact factor: 91.245

Review 2. The defense against hyperkalemia: the roles of insulin and aldosterone.

Authors: M Cox; R H Sterns; I Singer
Journal: N Engl J Med Date: 1978-09-07 Impact factor: 91.245

3. Isolated hypoaldosteronism in adults. A renin-deficiency syndrome.

Authors: M Schambelan; J R Stockigt; E G Biglieri
Journal: N Engl J Med Date: 1972-09-21 Impact factor: 91.245

4. Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis.

Authors: F Santeusanio; G R Faloona; J P Knochel; R H Unger
Journal: J Lab Clin Med Date: 1973-06

5. Paradoxical glucose-induced hyperkalemia. Combined aldosterone-insulin deficiency.

Authors: S Goldfarb; B Strunk; I Singer; M Goldberg
Journal: Am J Med Date: 1975-11 Impact factor: 4.965

6. Effect of acute hyperglycaemia on plasma potassium and aldosterone levels in type 2 (non-insulin-dependent) diabetes.

Authors: J Rosenstock; S A Loizou; I E Brajkovich; K Mashiter; G F Joplin
Journal: Diabetologia Date: 1982-03 Impact factor: 10.122

7. Factors contributing to deaths of diabetics under fifty years of age. On behalf of the Medical Services Study Group and British Diabetic Association.

Authors: W M Tunbridge
Journal: Lancet Date: 1981-09-12 Impact factor: 79.321

Hyperkalaemia in diabetes mellitus--potential hazards of coexisting hyporeninaemic hypoaldosteronism.

1. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism.

Review 2. The defense against hyperkalemia: the roles of insulin and aldosterone.

3. Isolated hypoaldosteronism in adults. A renin-deficiency syndrome.

4. Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis.

5. Paradoxical glucose-induced hyperkalemia. Combined aldosterone-insulin deficiency.

6. Effect of acute hyperglycaemia on plasma potassium and aldosterone levels in type 2 (non-insulin-dependent) diabetes.

7. Factors contributing to deaths of diabetics under fifty years of age. On behalf of the Medical Services Study Group and British Diabetic Association.

8. Acute hyperkalemia induced by hyperglycemia: hormonal mechanisms.

9. Hyporeninemic hypoaldosteronism. An overlooked cause of hyperkalemia.

10. Big renin and biosynthetic defect of aldosterone in diabetes mellitus.

1. Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases.

Review 2. The choice of antihypertensive therapy in the diabetic patient.

3. Type IV renal tubular acidosis and spironolactone therapy in the elderly.

4. Hyperkalaemia in diabetes: prevalence and associations.