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Literature DB >> 6376480

Droperidol vs. haloperidol in the initial management of acutely agitated patients.

Abstract

In a double-blind clinical study, 27 acutely agitated patients were treated with an intramuscular injection of 5 mg of droperidol or 5 mg of haloperidol from identical appearing vials. At 30 minutes following treatment, 81% of the patients treated with haloperidol but only 36% treated with droperidol required a second injection (p less than .05). Thus, droperidol, a safe butyrophenone neuroleptic, appears to be a drug of choice for rapid and reliable control of acute agitation.

Entities: Chemical Disease Species

Mesh：

Substances：
Haloperidol
Droperidol

Year: 1984 PMID： 6376480

Source DB: PubMed Journal: J Clin Psychiatry ISSN： 0160-6689 Impact factor: 4.384

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Cited

12 in total

Review 1. Clinical pharmacology of old age syndromes.

Authors: C Broadhurst; K C M Wilson; M T Kinirons; A Wagg; J K Dhesi
Journal: Br J Clin Pharmacol Date: 2003-09 Impact factor: 4.335

Review 2. [Psychotropic agents in emergency medicine].

Authors: A Wolf; M J Müller; F-G B Pajonk
Journal: Med Klin Intensivmed Notfmed Date: 2014-02 Impact factor: 0.840

Review 3. Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation).

Authors: Edoardo G Ostinelli; Melanie J Brooke-Powney; Xue Li; Clive E Adams
Journal: Cochrane Database Syst Rev Date: 2017-07-31

Review 4. Psychopharmacology of aggression in schizophrenia.

Authors: Peter Buckley; Leslie Citrome; Carmen Nichita; Michael Vitacco
Journal: Schizophr Bull Date: 2011-09 Impact factor: 9.306

Review 5. Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients.

Authors: B K Wagner; D A O'Hara
Journal: Clin Pharmacokinet Date: 1997-12 Impact factor: 6.447

Droperidol vs. haloperidol in the initial management of acutely agitated patients.

Review 1. Clinical pharmacology of old age syndromes.

Review 2. [Psychotropic agents in emergency medicine].

Review 3. Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation).

Review 4. Psychopharmacology of aggression in schizophrenia.

Review 5. Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients.

Review 6. Pharmacological treatment of psychotic agitation.

Review 7. Pharmacological management of acute agitation.

8. Comparison of droperidol and haloperidol for use by paramedics: assessment of safety and effectiveness.

Review 9. Pharmacological control of acute agitation: focus on intramuscular preparations.

Review 10. The pharmacologic management of delirium in children and adolescents.