| Literature DB >> 6375735 |
C Papanicolaou, M Dorizzi, J Ninio.
Abstract
A study of the polymerization/excision ratio in the replication of poly(dA), primed with oligo(dT), was carried out with E. coli DNA polymerase I, at various primer and enzyme concentrations. The variations in this ratio suggest that 1) the DNA polymerase is able to switch between two states of low and high exonuclease activities and 2) after dissociating from the template, the DNA polymerase drifts towards the low exonuclease state. The recovery of the high exonuclease state would require several successive incorporations.Entities:
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Year: 1984 PMID： 6375735 DOI： 10.1016/0300-9084(84)90199-8
Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079