Literature DB >> 637549

Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.

S Otten, J P Rosazza.   

Abstract

The naphthoquinone lapachol (1) is readily metabolized by several fungi and streptomycetes. Preparative-scale fermentations with Penicillium notatum (UI 1602) provided a major polar metabolite (4), which was isolated and identified as an intermediate of the Hooker oxidation. The metabolite was synthesized by reacting lapachol with hydrogen peroxide under alkaline conditions.

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Year:  1978        PMID： 637549      PMCID： PMC242878          DOI： 10.1128/aem.35.3.554-557.1978

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  5 in total

1.  Predominant Catalase-negative Soil Bacteria. III. Agromyces, gen. n., Microorganisms Intermediary to Actinomyces and Nocardia.

Authors:  W E Gledhill; L E Casida
Journal:  Appl Microbiol       Date:  1969-09

2.  Early clinical studies with lapachol (NSC-11905).

Authors:  J B Block; A A Serpick; W Miller; P H Wiernik
Journal:  Cancer Chemother Rep 2       Date:  1974-12

3.  Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata.

Authors:  R E Betts; D E Walters; J P Rosazza
Journal:  J Med Chem       Date:  1974-06       Impact factor: 7.446

4.  A lapachol derivative active against mouse lymphocytic leukemia P-388.

Authors:  M da Consolação; F Linardi; M M de Oliveira; M R Sampaio
Journal:  J Med Chem       Date:  1975-11       Impact factor: 7.446

5.  [Antimicrobial substances from higher plants. XXXV. Antimicrobial or antineoplastic activity of lawsona (2-hydroxy-1,4-naphthoquinone) in comparison with lapachol (2-hydroxy-3-(-3-methyl-2-butanyl)-1,4-naphthoquinone].

Authors:  O G de Lime; J S Coêlho; I L d' Albuquerque; J F de Mello; D G Martins; A L Lacerda; M A de Moraes e Souza
Journal:  Rev Inst Antibiot (Recife)       Date:  1971-06
  5 in total
  3 in total

1.  Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.

Authors:  S Otten; J P Rosazza
Journal:  Appl Environ Microbiol       Date:  1979-08       Impact factor: 4.792

2.  Structural transformation of methasterone with Cunninghamella blakesleeana and Macrophomina phaseolina.

Authors:  Muhammad Aamer; Mahwish Siddiqui; Almas Jabeen; Rimsha Irshad; Farooq-Ahmad Khan; M Iqbal Choudhary; Yan Wang
Journal:  RSC Adv       Date:  2022-03-25       Impact factor: 3.361

3.  Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2.

Authors:  Mani Shankar Babu; Sailendra Mahanta; Alexander J Lakhter; Takashi Hato; Subhankar Paul; Samisubbu R Naidu
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240
  3 in total

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