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Literature DB >> 6374381

Group A streptococcal phage T12 carries the structural gene for pyrogenic exotoxin type A.

Abstract

The structural gene for group A streptococcal pyrogenic exotoxin (SPE) type A was cloned into E. coli. DNA fragments used for cloning the toxin gene were isolated from bacteriophage T12. Toxin, present in cell lysates of E. coli clones, immunoprecipitated with antisera raised against purified SPE type A and formed a line of identity with streptococcal-derived A toxin. The cloned toxin shared the following biological activities with streptococcal A toxin: Pyrogenicity; enhancement of host susceptibility to lethal endotoxin shock; nonspecific lymphocyte mitogenicity; and alteration of immunoglobulin production. The physical location of the toxin gene on the phage T12 genome was determined.

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Year: 1984 PMID： 6374381 DOI： 10.1007/bf00383496

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

20 in total

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Authors: D A. Ritchie
Journal: FEBS Lett Date: 1970-12-11 Impact factor: 4.124

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Journal: Infect Immun Date: 1979-09 Impact factor: 3.441

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Authors: D B Clewell
Journal: J Bacteriol Date: 1972-05 Impact factor: 3.490

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Authors: D S Holmes; M Quigley
Journal: Anal Biochem Date: 1981-06 Impact factor: 3.365

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Authors: R G Duggleby; H Kinns; J I Rood
Journal: Anal Biochem Date: 1981-01-01 Impact factor: 3.365

6. A physical map of the group A streptococcal pyrogenic exotoxin bacteriophage T12 genome.

Authors: L P Johnson; P M Schlievert
Journal: Mol Gen Genet Date: 1983

7. Phage-host interactions and the production of type A streptococcal exotoxin in group A streptococci.

Authors: L McKane; J J Ferretti
Journal: Infect Immun Date: 1981-12 Impact factor: 3.441

8. Suppression of antibody response by group A streptococcal pyrogenic exotoxin and characterization of the cells involved.

Authors: C M Cunningham; D W Watson
Journal: Infect Immun Date: 1978-02 Impact factor: 3.441

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Authors: C M Cunningham; E L Barsumian; D W Watson
Journal: Infect Immun Date: 1976-09 Impact factor: 3.441

10. Group A streptococcal pyrogenic exotoxin: pyrogenicity, alteration of blood-brain barrier, and separation of sites for pyrogenicity and enhancement of lethal endotoxin shock.

Authors: P M Schlievert; D W Watson
Journal: Infect Immun Date: 1978-09 Impact factor: 3.441

40 in total

Review 1. Bacteriophage control of bacterial virulence.

Authors: Patrick L Wagner; Matthew K Waldor
Journal: Infect Immun Date: 2002-08 Impact factor: 3.441

2. The social evolution of bacterial pathogenesis.

Authors: J Smith
Journal: Proc Biol Sci Date: 2001-01-07 Impact factor: 5.349

3. Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

Authors: J M Musser; A R Hauser; M H Kim; P M Schlievert; K Nelson; R K Selander
Journal: Proc Natl Acad Sci U S A Date: 1991-04-01 Impact factor: 11.205

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Authors: C E Yu; J J Ferretti
Journal: Mol Gen Genet Date: 1991-12

5. Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci.

Authors: C E Yu; J J Ferretti
Journal: Infect Immun Date: 1991-01 Impact factor: 3.441

6. A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion.

Authors: P P Cleary; D LaPenta; R Vessela; H Lam; D Cue
Journal: Infect Immun Date: 1998-11 Impact factor: 3.441

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Authors: M Roggiani; J A Stoehr; B A Leonard; P M Schlievert
Journal: Infect Immun Date: 1997-07 Impact factor: 3.441

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Authors: C E Yu; J J Ferretti
Journal: Infect Immun Date: 1989-12 Impact factor: 3.441

9. The gene for type A streptococcal exotoxin (erythrogenic toxin) is located in bacteriophage T12.

Authors: C R Weeks; J J Ferretti
Journal: Infect Immun Date: 1984-11 Impact factor: 3.441

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Authors: A Norrby-Teglund; D Newton; M Kotb; S E Holm; M Norgren
Journal: Infect Immun Date: 1994-12 Impact factor: 3.441