Literature DB >> 6372685

Efficacy of aztreonam in treatment of experimental syphilis in rabbits.

S A Lukehart, S A Baker-Zander, K K Holmes.   

Abstract

The efficacy of aztreonam (SQ 26,776) in the therapy of active syphilis infection was evaluated in the rabbit model. Aztreonam was effective in treating active syphilis at a dose of 25 mg/kg given intramuscularly twice daily for 10 days; doses of 2.5 and 0.25 mg/kg were not effective.

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Year:  1984        PMID： 6372685      PMCID： PMC185528          DOI： 10.1128/AAC.25.3.390

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Cephalexin therapy for infectious syphilis.

Authors:  W C Duncan; J M Knox
Journal:  Arch Dermatol       Date:  1974-07

2.  The treatment of early syphilis with cephaloridine.

Authors:  A Gonzalez-Ochoa; J B Moreno
Journal:  Postgrad Med J       Date:  1967-08       Impact factor: 2.401

3.  On the antitreponemic action of cephaloridine.

Authors:  F Flarer
Journal:  Postgrad Med J       Date:  1967-08       Impact factor: 2.401

4.  Parenteral cephaloridine treatment of patients with early syphilis.

Authors:  J M Glicksman; D H Short; J M Knox
Journal:  Arch Intern Med       Date:  1968-04

5.  Effect of cortisone administration on host-parasite relationships in early experimental syphilis.

Authors:  S A Lukehart; S A Baker-Zander; R M Lloyd; S Sell
Journal:  J Immunol       Date:  1981-10       Impact factor: 5.422

6.  Cephalothin in the treatment of syphilis.

Authors:  G Nicolis; A Loucopoulos
Journal:  Br J Vener Dis       Date:  1974-08

7.  Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Authors:  R B Sykes; D P Bonner; K Bush; N H Georgopapadakou
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

8.  Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.

Authors:  S A Lukehart; S A Baker-Zander; S Sell
Journal:  J Immunol       Date:  1980-01       Impact factor: 5.422

9.  Mode of action of azthreonam.

Authors:  N H Georgopapadakou; S A Smith; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1982-06       Impact factor: 5.191

10.  Single-dose pharmacokinetics of the monobactam azthreonam (SQ 26,776) in healthy subjects.

Authors:  E A Swabb; A A Sugerman; T B Platt; F G Pilkiewicz; M Frantz
Journal:  Antimicrob Agents Chemother       Date:  1982-06       Impact factor: 5.191
  10 in total
  7 in total

1.  Treatment of uncomplicated gonorrhoea with single dose aztreonam.

Authors:  D T Evans; A J Crooks; C Jones; R A Holman; S W Price
Journal:  Genitourin Med       Date:  1986-10

2.  In vitro culture system to determine MICs and MBCs of antimicrobial agents against Treponema pallidum subsp. pallidum (Nichols strain).

Authors:  S J Norris; D G Edmondson
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

3.  Roxithromycin (RU 965): effective therapy for experimental syphilis infection in rabbits.

Authors:  S A Lukehart; S A Baker-Zander
Journal:  Antimicrob Agents Chemother       Date:  1987-02       Impact factor: 5.191

Review 4.  Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  R N Brogden; R C Heel
Journal:  Drugs       Date:  1986-02       Impact factor: 9.546

5.  Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection.

Authors:  R E Baughn; C Adams; D M Musher
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191

6.  Efficacy of cefmetazole in the treatment of active syphilis in the rabbit model.

Authors:  S A Baker-Zander; S A Lukehart
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

7.  Successful isolation of Treponema pallidum strains from patients' cryopreserved ulcer exudate using the rabbit model.

Authors:  Lara E Pereira; Samantha S Katz; Yongcheng Sun; Patrick Mills; Willie Taylor; Patricia Atkins; Charles M Thurlow; Kai-Hua Chi; Damien Danavall; Nicholas Cook; Tamanna Ahmed; Alyssa Debra; Susan Philip; Stephanie Cohen; Kimberly A Workowski; Ellen Kersh; Yetunde Fakile; Cheng Y Chen; Allan Pillay
Journal:  PLoS One       Date:  2020-01-13       Impact factor: 3.240
  7 in total

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