| Literature DB >> 6372654 |
Abstract
This chapter reviews the current concepts concerning the pathogenesis and treatment of lactic acidosis. The biochemistry of lactic acidosis and the physiology of lactate homeostasis, particularly as it relates to interorgan lactate flux and the role of the liver, are stressed. Limitations of bicarbonate therapy and the potential benefits of a new drug, dichloroacetate, in the treatment of lactic acidosis are discussed.Entities:
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Year: 1984 PMID: 6372654 DOI: 10.1146/annurev.me.35.020184.001145
Source DB: PubMed Journal: Annu Rev Med ISSN: 0066-4219 Impact factor: 13.739