Literature DB >> 6370838

Immunohistological demonstration of terminal transferase (TdT) in the age-involuted human thymus.

G G Steinmann, H K Müller-Hermelink.   

Abstract

By using a sensitive immunoperoxidase technique, serological determinants of terminal deoxynucleotidyl transferase (TdT, E. C. 2.7.7.31) were found in cortical lymphocytes of thymus biopsies of adult and aged persons (21-70 years) of both sexes. In contrast to biochemical determinations, specific immunohistological studies showed that TdT is continuously present in very large numbers of cortical thymic lymphocytes during human life, despite subtotal physiological involution of the thymus.

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Year:  1984        PMID: 6370838     DOI: 10.1016/S0171-2985(84)80142-4

Source DB:  PubMed          Journal:  Immunobiology        ISSN: 0171-2985            Impact factor:   3.144


  2 in total

Review 1.  Thymus: the next (re)generation.

Authors:  Mohammed S Chaudhry; Enrico Velardi; Jarrod A Dudakov; Marcel R M van den Brink
Journal:  Immunol Rev       Date:  2016-05       Impact factor: 12.988

2.  High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

Authors:  J M McCune; R Loftus; D K Schmidt; P Carroll; D Webster; L B Swor-Yim; I R Francis; B H Gross; R M Grant
Journal:  J Clin Invest       Date:  1998-06-01       Impact factor: 14.808

  2 in total

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