Literature DB >> 6370715

Effect of the rat liver S9 fraction on the mutagenicity of azathioprine in the Salmonella/mammalian microsome assay.

I Nepomnaschy, S E Sommer, R Nagel.   

Abstract

Azathioprine is a direct acting mutagen in Salmonella typhimurium TA100 and TA1535. Addition of rat liver S9 fraction with or without co-factors, or glutathione, causes a decrease in the mutagenicity of azathioprine in TA100 and an increase in TA1535, indicating the effect of SH groups.

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Year:  1984        PMID： 6370715     DOI： 10.1007/bf01952557

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Anti-heparin activity of lysosomal cationic proteins from polymorphonuclear leukocytes.

Authors:  H I Saba; H R Roberts; J C Herion
Journal:  Blood       Date:  1968-03       Impact factor: 22.113

3.  Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

Authors:  B N Ames; J Mccann; E Yamasaki
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433

4.  Induction of point mutations by different chemical mechanisms in the liver microsomal assay.

Authors:  B Herbold; W Buselmaier
Journal:  Mutat Res       Date:  1976-04       Impact factor: 2.433

5.  The mutagenic action of nitroimidazoles. IV. A comparison of the mutagenic action of several nitroimidazoles and some imidazoles.

Authors:  C E Voogd; J J van der Stel; J J Jacobs
Journal:  Mutat Res       Date:  1979-03       Impact factor: 2.433

6.  Assay of 855 test chemicals in ten tester strains using a new modification of the Ames test for bacterial mutagens.

Authors:  R E McMahon; J C Cline; C Z Thompson
Journal:  Cancer Res       Date:  1979-03       Impact factor: 12.701

7.  Mutagenicity of azathioprine.

Authors:  W T Speck; H S Rosenkranz
Journal:  Cancer Res       Date:  1976-01       Impact factor: 12.701

8.  Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

Authors:  B N Ames; W E Durston; E Yamasaki; F D Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

9.  Measurement of drug-metabolizing systems in Salmonella typhimurium strains G46, TA15135, TA100, TA1538 and TA98.

Authors:  J Meijer; J W DePierre; U Rannug
Journal:  Chem Biol Interact       Date:  1980-09       Impact factor: 5.192

10.  Glutathione and glutathione S-transferases in the Salmonella mammalian-microsome mutagenicity test.

Authors:  K H Summer; W Göggelmann; H Greim
Journal:  Mutat Res       Date:  1980-05       Impact factor: 2.433
  10 in total

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