Literature DB >> 6369335

In vivo localization of insulin binding to cells of the rat pancreas.

C Sakamoto, J A Williams, E Roach, I D Goldfine.   

Abstract

The uptake of 125I-insulin by rat pancreas was studied in vivo. Following fixation and light microscope autoradiography, saturable uptake of 125I-insulin was quantitatively demonstrated on acinar and duct cells but not on blood vessels and islets of Langerhans. Electron microscopy revealed the localization of 125I-insulin to the basolateral cell membranes of acinar and duct cells.

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Year:  1984        PMID： 6369335     DOI： 10.3181/00379727-175-41827

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  5 in total

Review 1.  Exocrine secretion of pancreatic hormones: possible mechanisms.

Authors:  P M Pour; R E Hauser
Journal:  Int J Pancreatol       Date:  1987-08

Review 2.  The islet-acinar axis of the pancreas.

Authors:  J von Schönfeld; H Goebell; M K Müller
Journal:  Int J Pancreatol       Date:  1994 Oct-Dec

3.  The exocrine pancreas in patients with hyperinsulinemic hypoglycemia. A morphometrical and ultrastructural study.

Authors:  D Bani; L Magnani; T B Sacchi; G Biliotti
Journal:  Int J Pancreatol       Date:  1989-10

4.  In situ binding of islet hormones in the isolated perfused rat pancreas: evidence for local high concentrations of islet hormones via the islet-acinar axis.

Authors:  A Nakagawa; J I Stagner; E Samols
Journal:  Diabetologia       Date:  1995-03       Impact factor: 10.122

5.  A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys.

Authors:  Sachiko Ohshima-Hosoyama; Heather A Simmons; Nichole Goecks; Valerie Joers; Christine R Swanson; Viktoriya Bondarenko; Rebecca Velotta; Kevin Brunner; Laura D Wood; Ralph H Hruban; Marina E Emborg
Journal:  PLoS One       Date:  2012-06-20       Impact factor: 3.240
  5 in total

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