Landmark article June 14, 1941: Sulfadiazine. Therapeutic evaluation and toxic effects on four hundred and forty-six patients. By Maxwell Finland, Elias Strauss, and Osler L. Peterson.

sulfadiazine appeared to be as effective as sulfapyridine or sulfathiazole in every condition in which it was used. Toxic effects from sulfadiazine were relatively mild and infrequent. Nausea and vomiting occurred in 9.2 per cent of the cases. Nitrogen retention of moderate degree was noted in 5 cases. Leukopenia occurred early and was transient in some cases. In 3 cases the leukocyte counts dropped between the eleventh and the sixteenth day and returned to normal on cessation of therapy. Morbilliform eruptions were observed in 9 cases