Literature DB >> 6365733

Apocrine differentiation in lobular carcinoma of the breast: a morphologic, immunologic, and ultrastructural study.

V Eusebi, C Betts, D E Haagensen, P Gugliotta, G Bussolati, J G Azzopardi.   

Abstract

The frequency of apocrine differentiation in breast carcinomas, assessed on purely morphologic grounds, is controversial. Apocrine differentiation in two cases of lobular carcinoma in situ (lobular neoplasia; LCIS) is reported for the first time. Using an immunohistochemical method for the detection of GCDFP-15, a protein present in apocrine epithelium and in the fluid of tension cysts of the breast, the apocrine differentiation in LCIS is confirmed. The histiocytoid variant of invasive lobular carcinoma is shown to be "apocrine" in nature, antigenically at least. The ultrastructural findings in one case of histiocytoid carcinoma are discussed in the context of an apparent discrepancy between the morphologic features of this tumor and the presence of an apocrine antigenic marker.

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Year:  1984        PMID： 6365733     DOI： 10.1016/s0046-8177(84)80053-2

Source DB:  PubMed          Journal:  Hum Pathol        ISSN： 0046-8177            Impact factor:   3.466


  18 in total

1.  Histiocytoid Breast Carcinoma: A Case Report with Immunohistochemical and Ultrastructural Studies.

Authors: 
Journal:  Breast Cancer       Date:  1996-03-29       Impact factor: 4.239

Review 2.  The enigmatic nature of apocrine breast lesions.

Authors:  P Zagorianakou; N Zagorianakou; D Stefanou; G Makrydimas; N J Agnantis
Journal:  Virchows Arch       Date:  2006-03-29       Impact factor: 4.064

3.  Invasive apocrine carcinoma of the breast: a long term follow-up study of 34 cases.

Authors:  E S d'Amore; M J Terrier-Lacombe; J P Travagli; S Friedman; G Contesso
Journal:  Breast Cancer Res Treat       Date:  1988-09       Impact factor: 4.872

4.  Androgen metabolism and apocrine differentiation in human breast cancer.

Authors:  W R Miller; J Telford; J M Dixon; A A Shivas
Journal:  Breast Cancer Res Treat       Date:  1985       Impact factor: 4.872

5.  Granular cell tumour of the breast.

Authors:  S Damiani; F C Koerner; G R Dickersin; M G Cook; V Eusebi
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

6.  Immunohistochemical markers in the identification of metastatic breast cancer.

Authors:  P C de Almeida; C B Pestana
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

7.  PIP/GCDFP-15 gene expression and apocrine differentiation in carcinomas of the breast.

Authors:  A Pagani; A Sapino; V Eusebi; P Bergnolo; G Bussolati
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

8.  Kappa casein, lactalbumin and GCDFP 70 localization in human breast carcinomas: an immunohistochemical study using the avidin-biotin-peroxidase complex method.

Authors:  C Charpin; P M Martin; A Lachard; J Jacquemier; M N Lavaut; C Andonian; N Pourreau-Schneider; M Toga
Journal:  Med Oncol Tumor Pharmacother       Date:  1985

9.  Apocrine carcinoma of the breast. A morphologic and immunocytochemical study.

Authors:  V Eusebi; R R Millis; M G Cattani; G Bussolati; J G Azzopardi
Journal:  Am J Pathol       Date:  1986-06       Impact factor: 4.307

10.  Intralobular growth of myoepithelial cell carcinoma of the breast.

Authors:  J Soares; G Tomasic; E Bucciarelli; V Eusebi
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064
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