Literature DB >> 6365593

Aldehydic peptides inhibiting renin.

J A Fehrentz, A Heitz, B Castro, C Cazaubon, D Nisato.   

Abstract

Aldehydic peptides in which the C terminal residue is leucinal or phenylalaninal were synthesized. These compounds exhibited potent inhibition of renin activity and appeared to be precursors of transition state analogues for renin-catalysed amide bond hydrolysis.

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Year:  1984        PMID: 6365593     DOI: 10.1016/0014-5793(84)80141-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  2 in total

Review 1.  Renin inhibitors.

Authors:  W J Greenlee
Journal:  Pharm Res       Date:  1987-10       Impact factor: 4.200

2.  Preparations of psi-peptide bond and peptide-aldehyde inhibitors of atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor.

Authors:  A Damodaran; R B Harris
Journal:  J Protein Chem       Date:  1995-08
  2 in total

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