Literature DB >> 6365235

Treating gonococcal urethritis in men: oral amoxycillin potentiated by clavulanate compared with intramuscular procaine penicillin.

A S Latif, J Sithole, S Bvumbe, B Gumbo, M Kawemba, R S Summers.   

Abstract

In a study of 121 men with uncomplicated gonococcal urethritis, 64 were treated orally with a single dose of 3 g amoxycillin and 250 mg of the specific beta-lactamase inhibitor, clavulanic acid, and 57 with a single intramuscular injection of 2.4 MU procaine penicillin. After seven days, six (9.4%) patients treated with amoxycillin and clavulanic acid were still culture positive for Neisseria gonorrhoeae, compared with 26.3% of those treated with procaine penicillin.

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Year:  1984        PMID： 6365235      PMCID： PMC1046265          DOI： 10.1136/sti.60.1.29

Source DB:  PubMed          Journal:  Br J Vener Dis        ISSN： 0007-134X


  3 in total

1.  Treatment of chancroid by clavulanic acid with amoxycillin in patients with beta-lactamase-positive Haemophilus ducreyi infection.

Authors:  M V Fast; H Nsanze; L J D'Costa; F A Plummer; P Karasira; I W Maclean; A R Ronald
Journal:  Lancet       Date:  1982-09-04       Impact factor: 79.321

2.  Treatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose.

Authors:  K C Mohanty; R B Roy
Journal:  Br J Vener Dis       Date:  1982-06

3.  Sexually, transmitted disease in clinic patients in Salisbury, Zimbabwe.

Authors:  A S Latif
Journal:  Br J Vener Dis       Date:  1981-06
  3 in total
  4 in total

1.  Incidence of gonorrhoea due to penicillinase producing Neisseria gonorrhoeae in Japan 1981-3 and treatment using a new antibiotic combination, BRL25000 (amoxycillin and clavulanic acid).

Authors:  K Osato; H Tsugami; K Harada; J Maruyama
Journal:  Genitourin Med       Date:  1986-06

Review 2.  Amoxicillin/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  P A Todd; P Benfield
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

3.  Single dose oral amoxycillin 3 g with either 125 mg or 250 mg clavulanic acid to treat uncomplicated anogenital gonorrhoea.

Authors:  A G Lawrence; D C Shanson
Journal:  Genitourin Med       Date:  1985-06

4.  Proposed interpretive criteria and quality control parameters for testing susceptibility of Neisseria gonorrhoeae to beta-lactam-clavulanate combinations.

Authors:  P C Fuchs; A L Barry; C N Baker; P R Murray; J A Washington
Journal:  J Clin Microbiol       Date:  1992-08       Impact factor: 5.948
  4 in total

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