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Literature DB >> 6363597

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells.

Abstract

The hypothesis that blocking of cytotoxic T lymphocyte (CTL)-mediated cytolysis with anti-Lyt-2 antibodies acts at the level of inhibiting the interaction of the Lyt-2-bearing structure with H-2 class I molecules was tested. In agreement with the findings of others, purified anti-Lyt-2.2 inhibited both antigen-specific lysis and lectin-dependent cellular cytotoxicity (LDCC). LDCC of H-2-positive and H-2-negative target cells was similarly inhibited by this antibody. As expected, this effect was specific for CTL expressing the Lyt-2.2 allele, in contrast to blocking with a rat monoclonal antibody to the murine LFA-1 antigen. The implications of this finding for the function of the Lyt-2 antigen in CTL-target cell interaction are discussed.

Entities: Disease Gene Species

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Year: 1984 PMID： 6363597 PMCID： PMC2187235 DOI： 10.1084/jem.159.2.551

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

20 in total

1. Regulation of cellular and humoral immune responses by T-cell subclasses.

Authors: H Cantor; E A Boyse
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

2. Studies on the induction and expression of T cell-mediated immunity. X. Inhibition by Lyt 2,3 antisera of cytotoxic T lymphocyte-mediated antigen-specific and -nonspecific cytotoxicity: evidence for the blocking of the binding between T lymphocytes and target cells and not the post-binding cytolytic steps.

Authors: J Fan; A Ahmed; B Bonavida
Journal: J Immunol Date: 1980-12 Impact factor: 5.422

3. Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

Authors: D Davignon; E Martz; T Reynolds; K Kürzinger; T A Springer
Journal: J Immunol Date: 1981-08 Impact factor: 5.422

4. Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences.

Authors: S L Swain; P R Panfili
Journal: J Immunol Date: 1979-02 Impact factor: 5.422

Review 5. The human T cell receptor: analysis with cytotoxic T cell clones.

Authors: E L Reinherz; S C Meuer; S F Schlossman
Journal: Immunol Rev Date: 1983 Impact factor: 12.988

6. Activation of T lymphocytes by lectins and carbohydrate-oxidizing reagents viewed as an immunological recognition of cell-surface modifications seen in the context of "self" major histocompatibility complex antigens.

Authors: A Kimura; B Ersson
Journal: Eur J Immunol Date: 1981-06 Impact factor: 5.532

7. The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells.

Authors: S L Swain; G Dennert; S Wormsley; R W Dutton
Journal: Eur J Immunol Date: 1981-03 Impact factor: 5.532

8. Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94 000 and 180 000 molecular weight.

Authors: M Pierres; C Goridis; P Golstein
Journal: Eur J Immunol Date: 1982-01 Impact factor: 5.532

9. T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis.

Authors: G Berke; E McVey; V Hu; W R Clark
Journal: J Immunol Date: 1981-08 Impact factor: 5.422

10. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity.

Authors: J A Ledbetter; W E Seaman; T T Tsu; L A Herzenberg
Journal: J Exp Med Date: 1981-06-01 Impact factor: 14.307

6 in total

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells.

1. Regulation of cellular and humoral immune responses by T-cell subclasses.

3. Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

4. Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences.

Review 5. The human T cell receptor: analysis with cytotoxic T cell clones.

6. Activation of T lymphocytes by lectins and carbohydrate-oxidizing reagents viewed as an immunological recognition of cell-surface modifications seen in the context of "self" major histocompatibility complex antigens.

7. The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells.

8. Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94 000 and 180 000 molecular weight.

9. T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis.

10. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity.

1. Isolation and properties of a Lyt-2.1-negative mutant of a Lyt-2.1/Lyt-2.2 CTL line.

2. Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant.

3. Direct evidence for binding of CD8 to HLA class I antigens.

4. Expression and function of CD8 in a murine T cell hybridoma.

5. The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.

6. Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone.