| Literature DB >> 6362662 |
Y S Zhang, Q P Cao, Z G Li, D F Cui.
Abstract
Des-(B25-B30)-hexapeptide-insulin with B23-glycine replaced by D-alanine was prepared by a combination of enzymic and non-enzymic syntheses. The purified product was homogeneous in polyacrylamide-gel electrophoresis and could be crystallized. The biological activity in vivo of crystalline [B23-D-Ala]des-(B25-B30)-hexapeptide-insulin was determined as 58% of that of standard pig insulin (27 i.u./mg).Entities:
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Year: 1983 PMID： 6362662 PMCID： PMC1152454 DOI： 10.1042/bj2150697
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857