Literature DB >> 6362554

High-pressure liquid chromatographic analysis of ceftazidime in serum and urine.

J S Leeder, M Spino, A M Tesoro, S M MacLeod.   

Abstract

A rapid and sensitive high-pressure liquid chromatographic procedure was developed for quantitative analysis of a new semisynthetic cephalosporin, ceftazidime, in serum and urine. A good linear relationship was established between peak height and the amount of ceftazidime injected over a concentration range of 1.9 to 30 micrograms/ml. Recovery was approximately 90% at concentrations of 3, 15, and 30 micrograms/ml. The method is specific for ceftazidime, with no interference noted from 11 other beta-lactam antibiotics tested. The assay is accurate, reproducible, and useful for pharmacokinetic studies in humans as demonstrated in two subjects.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6362554      PMCID： PMC185932          DOI： 10.1128/AAC.24.5.720

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Comparative activity in vitro of ceftazidime and nine other antibacterial agents.

Authors:  D S Reeves; H A Holt; M J Bywater
Journal:  Infection       Date:  1983       Impact factor: 3.553

2.  Comparative antipseudomonal activity of some newer beta-lactam agents.

Authors:  D Greenwood; A Eley
Journal:  Antimicrob Agents Chemother       Date:  1982-02       Impact factor: 5.191

3.  Comparison of in vitro activities of eight beta-lactamase-stable cephalosporins against beta-lactamase-producing gram-negative bacilli.

Authors:  L Verbist
Journal:  Antimicrob Agents Chemother       Date:  1981-03       Impact factor: 5.191

4.  Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa.

Authors:  H C Neu; P Labthavikul
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

5.  GR-20263: a new aminothiazolyl cephalosporin with high activity against Pseudomonas and Enterobacteriaceae.

Authors:  L Verbist; J Verhaegen
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191
  5 in total
  9 in total

1.  Disposition of ceftazidime in surgical patients with intra-abdominal infection.

Authors:  K L Heim-Duthoy; M P Bubrick; D M Cocchetto; G R Matzke
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

Review 2.  Penicillins and cephalosporins. Physicochemical properties and analysis in pharmaceutical and biological matrices.

Authors:  P C Van Krimpen; W P Van Bennekom; A Bult
Journal:  Pharm Weekbl Sci       Date:  1987-02-20

3.  Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child.

Authors:  G Koren; S Lavi; M Greenwald; C Roifman; J S Leeder; E W Gelfand; S M MacLeod
Journal:  Clin Pharmacokinet       Date:  1985 Jul-Aug       Impact factor: 6.447

4.  Recent analytical methods for cephalosporins in biological fluids.

Authors:  R D Toothaker; D S Wright; L A Pachla
Journal:  Antimicrob Agents Chemother       Date:  1987-08       Impact factor: 5.191

5.  Distribution of ceftazidime in ascitic fluid.

Authors:  G Benoni; E Arosio; M G Raimondi; E Apolloni; E Passarella; A Lechi; G P Velo
Journal:  Antimicrob Agents Chemother       Date:  1984-06       Impact factor: 5.191

6.  Kinetics of ceftazidime during plasmapheresis.

Authors:  F Bozkurt; P Schollmeyer; E Keller
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

7.  Efficacy of amikacin and ceftazidime in experimental aortic valve endocarditis due to Pseudomonas aeruginosa.

Authors:  A S Bayer; D Norman; K S Kim
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191

8.  Antimicrobial Peptide Novicidin Synergizes with Rifampin, Ceftriaxone, and Ceftazidime against Antibiotic-Resistant Enterobacteriaceae In Vitro.

Authors:  Odel Soren; Karoline Sidelmann Brinch; Dipesh Patel; Yingjun Liu; Alexander Liu; Anthony Coates; Yanmin Hu
Journal:  Antimicrob Agents Chemother       Date:  2015-07-27       Impact factor: 5.191

Review 9.  Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  D M Richards; R N Brogden
Journal:  Drugs       Date:  1985-02       Impact factor: 9.546
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.