Literature DB >> 6360407

Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O6-guanine position of dGTP.

D Toorchen, M D Topal.   

Abstract

The incorporation of O6-methyl-dGTP during DNA replication in vitro by 'Klenow' E. coli pol I was determined. O6-Methyl-dGTP was found to: (i) incorporate opposite T and C template residues, with a greater than 20-fold preference for T, and (ii) arrest DNA synthesis when incorporated in place of dATP at all but pyrimidine-rich growing-strand sequences. The significance of O6-methyl-dGTP incorporation during DNA biosynthesis in vivo for mutagenesis and carcinogenesis is discussed.

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Year:  1983        PMID： 6360407     DOI： 10.1093/carcin/4.12.1591

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  17 in total

1.  High-resolution structure of a mutagenic lesion in DNA.

Authors:  G A Leonard; J Thomson; W P Watson; T Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

Authors:  K Brown; A Buchmann; A Balmain
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

3.  Specificity and efficiency of editing of mismatches involved in the formation of base-substitution mutations by the 3'----5' exonuclease activity of phage T4 DNA polymerase.

Authors:  N K Sinha
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

4.  The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.

Authors:  Katherine Baran; Mao Yang; Christopher P Dillon; Leona L Samson; Douglas R Green
Journal:  Cell Death Differ       Date:  2017-07-28       Impact factor: 15.828

Review 5.  Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria.

Authors:  J P Claverys; S A Lacks
Journal:  Microbiol Rev       Date:  1986-06

Review 6.  Mispair formation in DNA can involve rare tautomeric forms in the template.

Authors:  P Strazewski
Journal:  Nucleic Acids Res       Date:  1988-10-25       Impact factor: 16.971

7.  Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

Authors:  D Chakravarti; J C Pelling; E L Cavalieri; E G Rogan
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205

8.  Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine.

Authors:  L D Williams; B R Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

9.  Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma.

Authors:  Yaoyao Su; Lihong Yin; Ran Liu; Jingyi Sheng; Miao Yang; Yi Wang; Enchun Pan; Wei Guo; Yuepu Pu; Juan Zhang; Geyu Liang
Journal:  Med Oncol       Date:  2013-12-24       Impact factor: 3.064

10.  O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

Authors:  S L Gerson; K Miller; N A Berger
Journal:  J Clin Invest       Date:  1985-12       Impact factor: 14.808
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