Literature DB >> 6360401

A phase II clinical trial of mefloquine in Brazilian male subjects.

J M de Souza.   

Abstract

Mefloquine was compared with sulfadoxine-pyrimethamine for safety and efficacy in a randomized, double-blind clinical trial in adult males from a malaria-endemic area of Brazil. A total of 99 oligosymptomatic and symptomatic volunteers with Plasmodium falciparum parasitaemia took part in the trial; 49 were given 1000 mg of mefloquine and the remainder received 1500 mg of sulfadoxine plus 75 mg of pyrimethamine, in a single oral dose.Mefloquine was 100% successful in clearing parasitaemia within 7 days; there were no recrudescences. Sulfadoxine-pyrimethamine was less successful; 35 cases showed an S-type response, 8 an RI response, 3 an RII, and 2 an RIII response. The side-effects of mefloquine were mild and transient and included headache, nausea, vomiting, dizziness, and diarrhoea. A satisfactory weight gain and rise in haemoglobin level were seen in both groups.

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Year:  1983        PMID： 6360401      PMCID： PMC2536166     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  5 in total

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Journal:  Hospital (Rio J)       Date:  1961-11

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Journal:  Southeast Asian J Trop Med Public Health       Date:  1982-03       Impact factor: 0.267

5.  Suppressive activity of mefloquine in sporozoite-induced human malaria.

Authors:  D F Clyde; V C McCarthy; R M Miller; R B Hornick
Journal:  Antimicrob Agents Chemother       Date:  1976-03       Impact factor: 5.191
  5 in total
  10 in total

1.  Pharmacokinetics of mefloquine in the presence of primaquine.

Authors:  J Karbwang; K Na Bangchang; A Thanavibul; D J Back; D Bunnag
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  Malaria-related anaemia: a Latin American perspective.

Authors:  Juan Pablo Quintero; André Machado Siqueira; Alberto Tobón; Silvia Blair; Alberto Moreno; Myriam Arévalo-Herrera; Marcus Vinícius Guimarães Lacerda; Sócrates Herrera Valencia
Journal:  Mem Inst Oswaldo Cruz       Date:  2011-08       Impact factor: 2.743

3.  A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria.

Authors:  J Karbwang; D J Back; D Bunnag; A M Breckenridge
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

4.  Effect of oral contraceptive steroids on the clinical course of malaria infection and on the pharmacokinetics of mefloquine in Thai women.

Authors:  J Karbwang; S Looareesuwan; D J Back; S Migasana; D Bunnag; A M Breckenridge
Journal:  Bull World Health Organ       Date:  1988       Impact factor: 9.408

Review 5.  New answers through chemotherapy?

Authors:  W Peters
Journal:  Experientia       Date:  1984-12-15

Review 6.  Clinical pharmacokinetics of mefloquine.

Authors:  J Karbwang; N J White
Journal:  Clin Pharmacokinet       Date:  1990-10       Impact factor: 6.447

7.  Mefloquine therapy for Plasmodium falciparum malaria in children under 5 years of age in Malawi: in vivo/in vitro efficacy and correlation of drug concentration with parasitological outcome.

Authors:  L M Slutsker; C O Khoromana; D Payne; C R Allen; J J Wirima; D L Heymann; L Patchen; R W Steketee
Journal:  Bull World Health Organ       Date:  1990       Impact factor: 9.408

8.  Pharmacokinetics of mefloquine in combination with sulfadoxine-pyrimethamine and primaquine in male Thai patients with falciparum malaria.

Authors:  J Karbwang; D J Back; D Bunnag; A M Breckenridge
Journal:  Bull World Health Organ       Date:  1990       Impact factor: 9.408

9.  Pharmacokinetics of mefloquine in children aged 6 to 24 months.

Authors:  V Singhasivanon; T Chongsuphajaisiddhi; A Sabcharoen; P Attanath; H K Webster; W H Wernsdorfer; U K Sheth; I Djaja Lika
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Oct-Dec       Impact factor: 2.441

10.  Prospective double-blind trial of two different doses of mefloquine plus pyrimethamine-sulfadoxine compared with pyrimethamine-sulfadoxine alone in the treatment of falciparum malaria.

Authors:  D Botero; M Restrepo; A Montoya
Journal:  Bull World Health Organ       Date:  1985       Impact factor: 9.408
  10 in total

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