Literature DB >> 6360173

Yeast pheromone alpha-factor is synthesized as a high molecular weight precursor.

O Emter, B Mechler, T Achstetter, H Müller, D H Wolf.   

Abstract

The sex pheromone alpha-factor of Saccharomyces cerevisiae, a tridecapeptide of approx. 1,700 molecular weight, was found to be synthesized in vivo as a high molecular weight precursor of Mr = 28,000. Inhibition of N-linked glycosylation by tunicamycin leads to three precursor species of lower molecular weight indicating three carbohydrate residues linked to the alpha-factor precursor molecule. A molecular weight of 18,000 was determined for the unglycosylated molecule.

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Year:  1983        PMID： 6360173     DOI： 10.1016/s0006-291x(83)80216-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Overexpression of an anti-CD3 immunotoxin increases expression and secretion of molecular chaperone BiP/Kar2p by Pichia pastoris.

Authors:  Yuan Yi Liu; Jung Hee Woo; David M Neville
Journal:  Appl Environ Microbiol       Date:  2005-09       Impact factor: 4.792

2.  Sheep pancreatic microsomes as an alternative to the dog source for studying protein translocation.

Authors:  M A Kaderbhai; V J Harding; A Karim; B M Austen; N N Kaderbhai
Journal:  Biochem J       Date:  1995-02-15       Impact factor: 3.857

Review 3.  Protein transport and compartmentation in yeast.

Authors:  J Horák
Journal:  Folia Microbiol (Praha)       Date:  1991       Impact factor: 2.099

4.  Secretion of foreign proteins from Saccharomyces cerevisiae directed by alpha-factor gene fusions.

Authors:  G A Bitter; K K Chen; A R Banks; P H Lai
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

5.  Glycosylation and structure of the yeast MF alpha 1 alpha-factor precursor is important for efficient transport through the secretory pathway.

Authors:  S Caplan; R Green; J Rocco; J Kurjan
Journal:  J Bacteriol       Date:  1991-01       Impact factor: 3.490

6.  Biogenesis of the yeast lysosome (vacuole): biosynthesis and maturation of proteinase yscB.

Authors:  B Mechler; H H Hirsch; H Müller; D H Wolf
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598

7.  Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection.

Authors:  A P Newman; S Ferro-Novick
Journal:  J Cell Biol       Date:  1987-10       Impact factor: 10.539

8.  The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.

Authors:  F Schimmöller; B Singer-Krüger; S Schröder; U Krüger; C Barlowe; H Riezman
Journal:  EMBO J       Date:  1995-04-03       Impact factor: 11.598

9.  Hormone processing and membrane-bound proteinases in yeast.

Authors:  T Achstetter; D H Wolf
Journal:  EMBO J       Date:  1985-01       Impact factor: 11.598
  9 in total

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