Literature DB >> 6358796

The synthesis of yeast pyruvate decarboxylase is regulated by large variations in the messenger RNA level.

H D Schmitt, M Ciriacy, F K Zimmermann.   

Abstract

The yeast PDC1 gene coding for the fermentative enzyme pyruvate decarboxylase was isolated. This DNA sequence was used to identify the corresponding messenger RNA by hybridization. It could be shown that the synthesis of pyruvate decarboxylase is efficiently regulated by variations in the amount of PDC1 mRNA. Very low levels of PDC1 mRNA were found in cells growing in a medium containing ethanol. Glucose addition to these cells leads to a rapid accumulation of PDC1 mRNA. The PDC1 mRNA levels found in different mutants and in cells growing in media containing carbon sources other than glucose or ethanol suggest that the amount of PDC1 mRNA in yeast cells is affected by a number of different factors.

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Year:  1983        PMID： 6358796     DOI： 10.1007/bf00327674

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  28 in total

1.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

2.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

3.  Transposable elements associated with constitutive expression of yeast alcohol dehydrogenase II.

Authors:  V M Williamson; E T Young; M Ciriacy
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

4.  A positive regulatory gene is required for accumulation of the functional messenger RNA for the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae.

Authors:  C L Denis; M Ciriacy; E T Young
Journal:  J Mol Biol       Date:  1981-06-05       Impact factor: 5.469

5.  The biochemical genetics of glycolysis in microbes.

Authors:  D G Fraenkel
Journal:  Basic Life Sci       Date:  1981

6.  Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

Authors:  G K McMaster; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

7.  Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene.

Authors:  K A Nasmyth; S I Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

8.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

9.  High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

Authors:  K Struhl; D T Stinchcomb; S Scherer; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

10.  Analysis of mutations affecting Ty-mediated gene expression in Saccharomyces cerevisiae.

Authors:  M Ciriacy; V M Williamson
Journal:  Mol Gen Genet       Date:  1981
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  38 in total

1.  Efficient production of L-Lactic acid by metabolically engineered Saccharomyces cerevisiae with a genome-integrated L-lactate dehydrogenase gene.

Authors:  Nobuhiro Ishida; Satoshi Saitoh; Kenro Tokuhiro; Eiji Nagamori; Takashi Matsuyama; Katsuhiko Kitamoto; Haruo Takahashi
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

2.  Glucose-induced regulatory defects in the Saccharomyces cerevisiae byp1 growth initiation mutant and identification of MIG1 as a partial suppressor.

Authors:  S Hohmann; K Huse; E Valentin; K Mbonyi; J M Thevelein; F K Zimmermann
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

3.  The glucose-and ethanol-dependent regulation of PDC1 from Saccharomyces cerevisiae are controlled by two distinct promoter regions.

Authors:  E Kellermann; C P Hollenberg
Journal:  Curr Genet       Date:  1988-10       Impact factor: 3.886

4.  Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis.

Authors:  A D Neale; R K Scopes; R E Wettenhall; N J Hoogenraad
Journal:  Nucleic Acids Res       Date:  1987-02-25       Impact factor: 16.971

5.  The structure and regulation of phosphoglucose isomerase in Saccharomyces cerevisiae.

Authors:  J B Green; A P Wright; W Y Cheung; W E Lancashire; B S Hartley
Journal:  Mol Gen Genet       Date:  1988-12

6.  The switch from fermentation to respiration in Saccharomyces cerevisiae is regulated by the Ert1 transcriptional activator/repressor.

Authors:  Najla Gasmi; Pierre-Etienne Jacques; Natalia Klimova; Xiao Guo; Alessandra Ricciardi; François Robert; Bernard Turcotte
Journal:  Genetics       Date:  2014-08-13       Impact factor: 4.562

7.  Maize pyruvate decarboxylase mRNA is induced anaerobically.

Authors:  P M Kelley
Journal:  Plant Mol Biol       Date:  1989-08       Impact factor: 4.076

8.  Switching the mode of metabolism in the yeast Saccharomyces cerevisiae.

Authors:  Karin Otterstedt; Christer Larsson; Roslyn M Bill; Anders Ståhlberg; Eckhard Boles; Stefan Hohmann; Lena Gustafsson
Journal:  EMBO Rep       Date:  2004-04-08       Impact factor: 8.807

9.  Yeast glycolytic mRNAs are differentially regulated.

Authors:  P A Moore; F A Sagliocco; R M Wood; A J Brown
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

10.  Induction of pyruvate decarboxylase in glycolysis mutants of Saccharomyces cerevisiae correlates with the concentrations of three-carbon glycolytic metabolites.

Authors:  E Boles; F K Zimmermann
Journal:  Arch Microbiol       Date:  1993       Impact factor: 2.552
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