| Literature DB >> 6358179 |
N M Boe, E P Dellinger, B H Minshew.
Abstract
The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were greater than 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhibited haemolysin production. Administration of clindamycin to rats with peritonitis due to haemolytic E. coli reduced mortality. Subinhibitory concentrations of clindamycin can inhibit growth and haemolysin production by E. coli and reduce mortality in an animal model of haemolytic E. coli peritonitis.Entities:
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Year: 1983 PMID： 6358179 DOI： 10.1093/jac/12.suppl_c.105
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790