Literature DB >> 6357906

Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between streptozotocin-treated rats and man.

R Crowe, J Lincoln, P F Blacklay, J P Pryor, J S Lumley, G Burnstock.   

Abstract

Vasoactive intestinal polypeptide (VIP) has been demonstrated by immunofluorescence histochemistry in nerves in human and rat penile tissue. A reduction in VIP-like immunoreactivity in nerves was revealed in tissue from streptozotocin-diabetic rats and a human diabetic with impotence. These results suggest that an impairment in the VIP-ergic innervation in penile tissue may be an important factor in the development of impotence in diabetes. They also support the view that the streptozotocin-treated rat is a useful experimental model for diabetic autonomic neuropathy.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6357906     DOI： 10.2337/diab.32.11.1075

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  9 in total

Review 1.  Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings.

Authors:  K E Andersson; F Holmquist
Journal:  World J Urol       Date:  1994       Impact factor: 4.226

Review 2.  Autonomic neuromuscular junctions: current developments and future directions.

Authors:  G Burnstock
Journal:  J Anat       Date:  1986-06       Impact factor: 2.610

3.  Vasoactive intestinal polypeptide levels and distribution in the penis of old rats.

Authors:  F Amenta; C Cavallotti; M De Rossi; F Ferrante; P Geppetti
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

4.  Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study.

Authors:  D M Levy; S S Karanth; D R Springall; J M Polak
Journal:  Diabetologia       Date:  1989-07       Impact factor: 10.122

5.  Early increase in CGRP- and VIP-immunoreactive nerves in the skin of streptozotocin-induced diabetic rats.

Authors:  S S Karanth; D R Springall; S Francavilla; D J Mirrlees; J M Polak
Journal:  Histochemistry       Date:  1990

6.  Elevated levels of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic Chinese hamsters.

Authors:  A R Diani; T Peterson; G A Sawada; B M Wyse; M C Blanks; G C Gerritsen; G Terenghi; I M Varndell; J M Polak; M A Blank
Journal:  Diabetologia       Date:  1985-05       Impact factor: 10.122

7.  A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model.

Authors:  I Gozes; M Fridkin
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

8.  Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocin-induced diabetes in the rat.

Authors:  M Ballmann; J M Conlon
Journal:  Diabetologia       Date:  1985-06       Impact factor: 10.122

9.  Experimental diabetes mellitus inhibits prostacyclin synthesis by the rat penis: pathological implications.

Authors:  J Y Jeremy; C S Thompson; D P Mikhailidis; P Dandona
Journal:  Diabetologia       Date:  1985-06       Impact factor: 10.122
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.