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Literature DB >> 6356739

Decreased insulin binding to red blood cells in liver cirrhosis.

A V Greco, A Bentoli, S Caputo, L Altomonte, R Manna, G Ghirlanda.

Abstract

eleven male cirrhotic subjects, all with impaired glucose tolerance (IGT), were studied. Insulin binding to circulating erythrocytes was evaluated. The specific bound fraction was decreased compared to normals (5.95 +/-0.76 vs 7.08 +/- 0.84%; p less than 0.005). An negative correlation was found between fasting insulin and bound fraction (r = -0.68; p less than 0.05). We suggest that serum insulin may be chronically augmented as a consequence of liver damage. This induces a down-regulation of insulin receptors that is responsible for insulin resistance and at least in part for the impairment of glucose tolerance.

Entities: Disease Gene

Mesh：

Substances：
Insulin

Year: 1983 PMID： 6356739 DOI： 10.1007/bf02581269

Source DB: PubMed Journal: Acta Diabetol Lat ISSN： 0001-5563

19 in total

1. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis.

Authors: A V Greco; F Crucitti; G Ghirlanda; R Manna; L Altomonte; A G Rebuzzi; A Bertoli
Journal: Diabetologia Date: 1979-07 Impact factor: 10.122

2. Coated charcoal immunoassay of insulin.

Authors: V Herbert; K S Lau; C W Gottlieb; S J Bleicher
Journal: J Clin Endocrinol Metab Date: 1965-10 Impact factor: 5.958

3. Acid hydrolases in monocytes from patients with inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis.

Authors: N K Ganguly; J G Kingham; B Lloyd; R S Lloyd; C P Price; D R Triger; R Wright
Journal: Lancet Date: 1978-05-20 Impact factor: 79.321

4. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity.

Authors: Y Harano; S Ohgaku; H Hidaka; K Haneda; R Kikkawa; Y Shigeta; H Abe
Journal: J Clin Endocrinol Metab Date: 1977-11 Impact factor: 5.958

5. Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding during the menstrual cycle.

Authors: A Bertoli; R De Pirro; A Fusco; A V Greco; R Magnatta; R Lauro
Journal: J Clin Endocrinol Metab Date: 1980-02 Impact factor: 5.958

Decreased insulin binding to red blood cells in liver cirrhosis.

1. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis.

2. Coated charcoal immunoassay of insulin.

3. Acid hydrolases in monocytes from patients with inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis.

4. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity.

5. Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding during the menstrual cycle.

6. Cholic acid synthesis as an index of the severity of liver disease in man.

7. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

8. Degradation and secretion of insulin in hepatic cirrhosis.

9. Insulin resistance in liver cirrhosis: decreased insulin binding to circulating monocytes.

10. Hyperinsulinism of hepatic cirrhosis: Diminished degradation or hypersecretion?

1. Insulin binding to erythrocytes in hyperinsulinemic patients with precirrhotic hemochromatosis and cirrhosis.

2. Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect.