Literature DB >> 6356505

Effects of qinghaosu and related compounds on incorporation of [G-3H] hypoxanthine by Plasmodium falciparum in vitro.

Z L Li, H M Gu, D C Warhurst, W Peters.   

Abstract

The effects of qinghaosu (QHS), dihydroqinghaosu (DHQ), artemether and alpha-propoxycarbonyl dihydroartemisine (SM242) on incorporation of [G-3H] hypoxanthine into Plasmodium falciparum were studied in vitro. Antimalarial activity in vitro is enhanced by reduction of the keto group, since DHQ, artemether and SM242 were more than 100 times more active than QHS.

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Year:  1983        PMID： 6356505     DOI： 10.1016/0035-9203(83)90129-3

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  10 in total

1.  Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects.

Authors:  T K Dien; P J de Vries; N X Khanh; R Koopmans; L N Binh; D D Duc; P A Kager; C J van Boxtel
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

Review 2.  New answers through chemotherapy?

Authors:  W Peters
Journal:  Experientia       Date:  1984-12-15

Review 3.  Artemisia annua L.: a source of novel antimalarial drugs.

Authors:  H J Woerdenbag; C B Lugt; N Pras
Journal:  Pharm Weekbl Sci       Date:  1990-10-19

4.  Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum.

Authors:  N Kumar; H Zheng
Journal:  Parasitol Res       Date:  1990       Impact factor: 2.289

Review 5.  Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria.

Authors:  P J de Vries; T K Dien
Journal:  Drugs       Date:  1996-12       Impact factor: 9.546

6.  Antimalarial Natural Products.

Authors:  David G I Kingston; Maria Belen Cassera
Journal:  Prog Chem Org Nat Prod       Date:  2022

7.  In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni.

Authors:  S H Xiao; B A Catto
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

8.  Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives.

Authors:  O Y Ke; E C Krug; J J Marr; R L Berens
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

9.  Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro.

Authors:  Steven P Maher; Amélie Vantaux; Victor Chaumeau; Adeline C Y Chua; Caitlin A Cooper; Chiara Andolina; Julie Péneau; Mélanie Rouillier; Zaira Rizopoulos; Sivchheng Phal; Eakpor Piv; Chantrea Vong; Sreyvouch Phen; Chansophea Chhin; Baura Tat; Sivkeng Ouk; Bros Doeurk; Saorin Kim; Sangrawee Suriyakan; Praphan Kittiphanakun; Nana Akua Awuku; Amy J Conway; Rays H Y Jiang; Bruce Russell; Pablo Bifani; Brice Campo; François Nosten; Benoît Witkowski; Dennis E Kyle
Journal:  Sci Rep       Date:  2021-10-07       Impact factor: 4.379

10.  Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro.

Authors:  Sen Wang; Muxiao Li; Xiaoying Luo; Long Yu; Zheng Nie; Qin Liu; Xiaomeng An; Yangsiqi Ao; Qin Liu; Jiaxu Chen; Yu Tian; Junlong Zhao; Lan He
Journal:  Front Cell Dev Biol       Date:  2020-04-28
  10 in total

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